Effects of ACE2 deficiency on physical performance and physiological adaptations of cardiac and skeletal muscle to exercise
| Autor: | Valentina Mosienko, Robson A.S. Santos, Daisy Motta-Santos, Marko Poglitsch, Natalia Alenina, Michael Bader, Fatimunnisa Qadri, Marilene L. Oliveira, Maria José Campagnole-Santos, Joseph M. Penninger, Lenice Kappes Becker |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Angiotensins Physiology 030204 cardiovascular system & hematology Peptidyl-Dipeptidase A 03 medical and health sciences Mice 0302 clinical medicine Internal medicine Renin–angiotensin system Gene expression Internal Medicine medicine Animals Humans Muscle Skeletal Exercise chemistry.chemical_classification Angiotensin II receptor type 1 business.industry Myocardium Skeletal muscle Heart Adaptation Physiological Cardiovascular physiology Mice Inbred C57BL Physiological Adaptations medicine.anatomical_structure Endocrinology Enzyme chemistry Ventricle Exercise Test Angiotensin-Converting Enzyme 2 Cardiology and Cardiovascular Medicine business hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery |
| Zdroj: | Hypertension research : official journal of the Japanese Society of Hypertension. 39(7) |
| ISSN: | 1348-4214 |
| Popis: | The renin-angiotensin system (RAS) is related to physiological adaptations induced by exercise. Angiotensin-converting enzyme (ACE) 2 is a major regulator of the RAS in tissues, as it metabolizes angiotensin (Ang) II to Ang-(1-7). The aim of this study was to determine the effects of ACE2 deficiency on physical performance and physiological adaptations induced by voluntary running. Physical performance, body composition and plasma angiotensin levels, as well as tissue morphology and gene expression of RAS components in the left ventricle (LV) and skeletal muscle (gastrocnemius), were evaluated in ACE2-deficient (ACE2(-/y)) and wild-type (ACE2(+/y)) mice after 6 weeks of voluntary wheel running. ACE2(-/y) mice run less than ACE2(+/y) mice (19±4.7 vs. 26±12.6 revolutions per day × 100, P |
| Databáze: | OpenAIRE |
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