Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study

Autor: Kristina En Petersen, Emily Sonestedt, Idlir Licaj, Heather Ward, Aurora Perez-Cornago, Petra H.M. Peeters, Verena Katzke, Anna Winkvist, Claire Cadeau, Robin Myte, Konstantinos K. Tsilidis, Nada Assi, Ulrika Ericson, Christina C. Dahm, Antonia Trichopoulou, Heinz Freisling, Christina Bamia, Camilla Plambeck Hansen, Mazda Jenab, Graham Byrnes, Marc J. Gunter, Giovanna Masala, Nicholas J. Wareham, José Ramón Quirós, Carlotta Sacerdote, Tilman Kühn, Heiner Boeing, Dagrun Engeset, Guri Skeie, Aurelie Moskal, Nadia Slimani, Sabina Sieri, Khalid Iqbal, Eva Ardanaz, Aurélie Affret, Bas Bueno-de-Mesquita, Anne Tjønneland, Maria Santucci de Magistris, Elena Molina-Portillo, Inge Huybrechts, José María Huerta Castaño, Pilar Amiano, Kay-Tee Khaw, Pietro Ferrari, Marie-Christine Boutron-Ruault, Michael T. Fahey, Genevieve Buckland, Rosario Tumino, Androniki Naska
Přispěvatelé: Wareham, Nicholas [0000-0003-1422-2993], Khaw, Kay-Tee [0000-0002-8802-2903], Apollo - University of Cambridge Repository
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Oncology
Adult
Male
medicine.medical_specialty
Cancer Research
Epidemiology
Colorectal cancer
dietary patterns
Nutritional Status
colon
rectum
nutrients
EPIC
Europe
PCA
03 medical and health sciences
Prostate cancer
0302 clinical medicine
Breast cancer
Risk Factors
Internal medicine
medicine
Journal Article
Humans
Oncology & Carcinogenesis
Prospective Studies
Prospective cohort study
2. Zero hunger
Cervical cancer
030109 nutrition & dietetics
business.industry
VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762
Cancer
Middle Aged
medicine.disease
3. Good health
European Prospective Investigation into Cancer and Nutrition
Multicenter Study
VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762
030220 oncology & carcinogenesis
Female
Skin cancer
business
Colorectal Neoplasms
1112 Oncology And Carcinogenesis
Zdroj: British Journal of Cancer, 115(11), 1430. Nature Publishing Group
British Journal of Cancer
Moskal, A, Freisling, H, Byrnes, G, Assi, N, Fahey, M T, Jenab, M, Ferrari, P, Tjønneland, A, Petersen, K E, Dahm, C C, Hansen, C P, Affret, A, Boutron-Ruault, M-C, Cadeau, C, Kühn, T, Katzke, V, Iqbal, K, Boeing, H, Trichopoulou, A, Bamia, C, Naska, A, Masala, G, de Magistris, M S, Sieri, S, Tumino, R, Sacerdote, C, Peeters, P H, Bueno-de-Mesquita, B H, Engeset, D, Licaj, I, Skeie, G, Ardanaz, E, Buckland, G, Castaño, J M H, Quirós, J R, Amiano, P, Molina-Portillo, E, Winkvist, A, Myte, R, Ericson, U, Sonestedt, E, Perez-Cornago, A, Wareham, N, Khaw, K-T, Huybrechts, I, Tsilidis, K K, Ward, H, Gunter, M J & Slimani, N 2016, ' Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study ', B J C, vol. 115, no. 11, pp. 1430–1440 . https://doi.org/10.1038/bjc.2016.334
ISSN: 0007-0920
Popis: BACKGROUND: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.METHODS: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.RESULTS: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.CONCLUSIONS: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.British Journal of Cancer advance online publication 20 October 2016; doi:10.1038/bjc.2016.334 www.bjcancer.com.
Databáze: OpenAIRE
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