Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
Autor: | Kristina En Petersen, Emily Sonestedt, Idlir Licaj, Heather Ward, Aurora Perez-Cornago, Petra H.M. Peeters, Verena Katzke, Anna Winkvist, Claire Cadeau, Robin Myte, Konstantinos K. Tsilidis, Nada Assi, Ulrika Ericson, Christina C. Dahm, Antonia Trichopoulou, Heinz Freisling, Christina Bamia, Camilla Plambeck Hansen, Mazda Jenab, Graham Byrnes, Marc J. Gunter, Giovanna Masala, Nicholas J. Wareham, José Ramón Quirós, Carlotta Sacerdote, Tilman Kühn, Heiner Boeing, Dagrun Engeset, Guri Skeie, Aurelie Moskal, Nadia Slimani, Sabina Sieri, Khalid Iqbal, Eva Ardanaz, Aurélie Affret, Bas Bueno-de-Mesquita, Anne Tjønneland, Maria Santucci de Magistris, Elena Molina-Portillo, Inge Huybrechts, José María Huerta Castaño, Pilar Amiano, Kay-Tee Khaw, Pietro Ferrari, Marie-Christine Boutron-Ruault, Michael T. Fahey, Genevieve Buckland, Rosario Tumino, Androniki Naska |
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Přispěvatelé: | Wareham, Nicholas [0000-0003-1422-2993], Khaw, Kay-Tee [0000-0002-8802-2903], Apollo - University of Cambridge Repository |
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
Oncology Adult Male medicine.medical_specialty Cancer Research Epidemiology Colorectal cancer dietary patterns Nutritional Status colon rectum nutrients EPIC Europe PCA 03 medical and health sciences Prostate cancer 0302 clinical medicine Breast cancer Risk Factors Internal medicine medicine Journal Article Humans Oncology & Carcinogenesis Prospective Studies Prospective cohort study 2. Zero hunger Cervical cancer 030109 nutrition & dietetics business.industry VDP::Medical disciplines: 700::Clinical medical disciplines: 750::Oncology: 762 Cancer Middle Aged medicine.disease 3. Good health European Prospective Investigation into Cancer and Nutrition Multicenter Study VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Onkologi: 762 030220 oncology & carcinogenesis Female Skin cancer business Colorectal Neoplasms 1112 Oncology And Carcinogenesis |
Zdroj: | British Journal of Cancer, 115(11), 1430. Nature Publishing Group British Journal of Cancer Moskal, A, Freisling, H, Byrnes, G, Assi, N, Fahey, M T, Jenab, M, Ferrari, P, Tjønneland, A, Petersen, K E, Dahm, C C, Hansen, C P, Affret, A, Boutron-Ruault, M-C, Cadeau, C, Kühn, T, Katzke, V, Iqbal, K, Boeing, H, Trichopoulou, A, Bamia, C, Naska, A, Masala, G, de Magistris, M S, Sieri, S, Tumino, R, Sacerdote, C, Peeters, P H, Bueno-de-Mesquita, B H, Engeset, D, Licaj, I, Skeie, G, Ardanaz, E, Buckland, G, Castaño, J M H, Quirós, J R, Amiano, P, Molina-Portillo, E, Winkvist, A, Myte, R, Ericson, U, Sonestedt, E, Perez-Cornago, A, Wareham, N, Khaw, K-T, Huybrechts, I, Tsilidis, K K, Ward, H, Gunter, M J & Slimani, N 2016, ' Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study ', B J C, vol. 115, no. 11, pp. 1430–1440 . https://doi.org/10.1038/bjc.2016.334 |
ISSN: | 0007-0920 |
Popis: | BACKGROUND: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study.METHODS: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors.RESULTS: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk.CONCLUSIONS: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.British Journal of Cancer advance online publication 20 October 2016; doi:10.1038/bjc.2016.334 www.bjcancer.com. |
Databáze: | OpenAIRE |
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