Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia [see comments]
| Autor: | John S. Abrams, Thomas Hogan, Dan Hardy, TC Meeker, Cheryl L. Willman |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Macrophage colony-stimulating factor
Immunology Chromosomal translocation Gene rearrangement Cell Biology Hematology Biology medicine.disease Biochemistry Paracrine signalling Leukemia Granulocyte macrophage colony-stimulating factor hemic and lymphatic diseases Acute lymphocytic leukemia medicine Cancer research Eosinophilia medicine.symptom Autocrine signalling medicine.drug Interleukin 3 |
| Zdroj: | Blood. 76:285-289 |
| ISSN: | 1528-0020 0006-4971 |
| DOI: | 10.1182/blood.v76.2.285.bloodjournal762285 |
| Popis: | The t(5;14)(q31;q32) translocation from B-lineage acute lymphocytic leukemia with eosinophilia has been cloned from two leukemia samples. In both cases, this translocation joined the IgH gene and the interleukin-3 (IL-3) gene. In one patient, excess IL-3 mRNA was produced by the leukemic cells. In the second patient, serum IL-3 levels were measured and shown to correlate with disease activity. There was no evidence of excess granulocyte/macrophage colony stimulating factor (GM-CSF) or IL-5 expression. Our data support the formulation that this subtype of leukemia may arise in part because of a chromosome translocation that activates the IL-3 gene, resulting in autocrine and paracrine growth effects. |
| Databáze: | OpenAIRE |
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