Pathological findings from synovium of early osteoarthritic knee joints with persistent hydrarthrosis
| Autor: | Rie Kurose, Norito Yagihashi, Hiroyuki Akimoto, Hiroshi Kakizaki, Takashi Sawai |
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| Rok vydání: | 2014 |
| Předmět: |
musculoskeletal diseases
0301 basic medicine Male medicine.medical_specialty Pathology Time Factors Knee Joint Severity of Illness Index Pathogenesis 03 medical and health sciences 0302 clinical medicine Rheumatology Synovectomy medicine Humans Interleukin 6 Pathological Aged Cell Proliferation 030203 arthritis & rheumatology biology Hydrarthrosis business.industry Interleukin-6 Tumor Necrosis Factor-alpha Synovial Membrane Histology Fibroblasts Middle Aged Osteoarthritis Knee musculoskeletal system medicine.disease 030104 developmental biology Rheumatoid arthritis biology.protein Disease Progression Histopathology Female Matrix Metalloproteinase 3 business |
| Zdroj: | International journal of rheumatic diseases. 19(5) |
| ISSN: | 1756-185X |
| Popis: | Aim Nonspecific chronic synovitis of the knee joint was reported by Pollard in 1962 and its pathogenesis is considered to be a physiological reaction to intra-articular disease. In this study, we evaluated the pathological findings of the synovium of early osteoarthritis (OA)-affected knee joints with hydrarthrosis in comparison to typical OA. Methods Synovial tissues were harvested from early OA knee joints with hydrarthrosis graded 0–2 according to the Kellgren and Lawrence classification and examined by histopathology. Results The synovial tissues showed proliferation of fibroblast-like synoviocytes (FLS) as if in rheumatoid arthritis (RA), and were immunohistochemically positive for matrix metalloproteinase 3, tumor necrosis factor α and interleukin 6. Conclusions The histology of RA is characterized by marked proliferation of FLS. In this study, the synovial tissues of early OA with hydrarthrosis showed moderate FLS proliferation. They also expressed the cytokines that are detected in the synovial tissues of RA. We suggest long-term follow-up is needed because early OA with hydrarthrosis might progress to overt RA. |
| Databáze: | OpenAIRE |
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