HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound
| Autor: | Ole Schmeltz Søgaard, Saheli Sadanand, Zelda Euler, Dan H. Barouch, Galit Alter, Douglas A. Lauffenburger, Caitlyn Linde, Jessica K. Sassic, Thomas A Rasmussen, Stephanie Fischinger, Martin Tolstrup, Madeleine F. Jennewein, Todd J. Suscovich, Giuseppe Lofano, Richelle C. Charles, Eileen P. Scully, Selena Vigano, Lu Zheng, Rasmus Offersen, Boris Julg, Lars Østergaard, Kathryn E. Stephenson, Mathias Lichterfeld, Marcus Altfeld, Erik S. Rosenberg, Dario Garcia-Dominguez, Wen-Han Yu, Todd M. Allen |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Glycosylation Fc-receptors glycosylation viral host response Human immunodeficiency virus (HIV) Inflammation HIV Antibodies medicine.disease_cause HIV reservoir General Biochemistry Genetics and Molecular Biology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine N-linked glycosylation medicine Humans antibodies lcsh:QH301-705.5 B cells biology business.industry biomarkers HIV Viral Load cure Discontinuation Vaccination 030104 developmental biology lcsh:Biology (General) chemistry HIV remission Immunology biology.protein Biomarker (medicine) Antibody medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Offersen, R, Yu, W H, Scully, E P, Julg, B, Euler, Z, Sadanand, S, Garcia-Dominguez, D, Zheng, L, Rasmussen, T A, Jennewein, M F, Linde, C, Sassic, J, Lofano, G, Vigano, S, Stephenson, K E, Fischinger, S, Suscovich, T J, Lichterfeld, M, Lauffenburger, D, Rosenberg, E S, Allen, T, Altfeld, M, Charles, R C, Østergaard, L, Tolstrup, M, Barouch, D H, Søgaard, O S & Alter, G 2020, ' HIV Antibody Fc N-Linked Glycosylation Is Associated with Viral Rebound ', Cell Reports, vol. 33, no. 11, 108502 . https://doi.org/10.1016/j.celrep.2020.108502 Cell Reports, Vol 33, Iss 11, Pp 108502-(2020) |
| DOI: | 10.1016/j.celrep.2020.108502 |
| Popis: | Summary: Changes in antibody glycosylation are linked to inflammation across several diseases. Alterations in bulk antibody galactosylation can predict rheumatic flares, act as a sensor for immune activation, predict gastric cancer relapse, track with biological age, shift with vaccination, change with HIV reservoir size on therapy, and decrease in HIV and HCV infections. However, whether changes in antibody Fc biology also track with reservoir rebound time remains unclear. The identification of a biomarker that could forecast viral rebound time could significantly accelerate the downselection and iterative improvement of promising HIV viral eradication strategies. Using a comprehensive antibody Fc-profiling approach, the level of HIV-specific antibody Fc N-galactosylation is significantly associated with time to rebound after treatment discontinuation across three independent cohorts. Thus virus-specific antibody glycosylation may represent a promising, simply measured marker to track reservoir reactivation. |
| Databáze: | OpenAIRE |
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