Bread Affects Clinical Parameters and Induces Gut Microbiome-Associated Personal Glycemic Responses
| Autor: | Noa Kosower, Maya Lotan-Pompan, Adina Weinberger, Jotham Suez, David Zeevi, Noam Bar, Tal Korem, Omer Weissbrod, Ben Z. Goldberg, Niv Zmora, Eran Segal, Tali Avnit-Sagi, Eran Elinav, Michal Rein, Avraham A. Levy, Gal Malka |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Adult Blood Glucose Male Physiology Biology Gut flora 03 medical and health sciences Dietary interventions Humans Microbiome Food science Molecular Biology Glycemic 030109 nutrition & dietetics Cross-Over Studies digestive oral and skin physiology food and beverages Cell Biology Bread Middle Aged biology.organism_classification Differential effects Crossover study Gut microbiome Gastrointestinal Microbiome 030104 developmental biology Female |
| Zdroj: | Cell metabolism. 25(6) |
| ISSN: | 1932-7420 |
| Popis: | Bread is consumed daily by billions of people, yet evidence regarding its clinical effects is contradicting. Here, we performed a randomized crossover trial of two 1-week-long dietary interventions comprising consumption of either traditionally made sourdough-leavened whole-grain bread or industrially made white bread. We found no significant differential effects of bread type on multiple clinical parameters. The gut microbiota composition remained person specific throughout this trial and was generally resilient to the intervention. We demonstrate statistically significant interpersonal variability in the glycemic response to different bread types, suggesting that the lack of phenotypic difference between the bread types stems from a person-specific effect. We further show that the type of bread that induces the lower glycemic response in each person can be predicted based solely on microbiome data prior to the intervention. Together, we present marked personalization in both bread metabolism and the gut microbiome, suggesting that understanding dietary effects requires integration of person-specific factors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|