Levels of heparin-releasable TFPI are increased in first-ever lacunar stroke patients
| Autor: | José W. P. Govers-Riemslag, R. J. van Oostenbrugge, Julie Staals, Kristien Winckers, Otto Bekers, Rob P.W. Rouhl, Iris L.H. Knottnerus, H. ten Cate, Jan Lodder, Tilman M. Hackeng |
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| Přispěvatelé: | MUMC+: DA CDL Algemeen (9), Cardiologie, RS: CARIM School for Cardiovascular Diseases, RS: MHeNs School for Mental Health and Neuroscience, Promovendi CD, Interne Geneeskunde, Biochemie, Klinische Neurowetenschappen, MUMC+: MA Med Staf Spec Neurologie (9) |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Lacunar stroke Denmark Lipoproteins Enzyme-Linked Immunosorbent Assay Brain Ischemia Endothelial activation Pathogenesis Tissue factor pathway inhibitor Clinical Protocols Risk Factors Internal medicine medicine Image Processing Computer-Assisted Humans In patient Prospective Studies Registries Aged business.industry Heparin Age Factors Anticoagulants Plasma levels Middle Aged medicine.disease Magnetic Resonance Imaging Pathophysiology Endocrinology Logistic Models Stroke Lacunar Female Neurology (clinical) Endothelium Vascular business Biomarkers medicine.drug |
| Zdroj: | Neurology, 78(7), 493-498. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 1526-632X 0028-3878 |
| DOI: | 10.1212/WNL.0b013e318246d6b7 |
| Popis: | Objectives: New insights in the pathophysiology of lacunar stroke (LS) suggest that it is caused by increased permeability of the blood-brain barrier due to endothelial activation. Because endothelial cells are the major production and storage site of tissue factor pathway inhibitor (TFPI), this protein can be used as marker of endothelial activation. In this observational study we measured the different pools of TFPI, as a marker of endothelial function, in first-ever lacunar stroke patients. Methods: We determined antigen levels of total and free full-length (FL) TFPI using ELISA in 149 patients and 42 controls. Heparin-releasable free FL TFPI was determined in a random subset of 17 patients and 15 controls. By brain MRI, we classified LS patients as having isolated lacunar infarct (ILA) or silent ischemic lesions (SILs). Results: Plasma levels of total TFPI were highest in patients with SILs compared with those with ILA, but this association disappeared after correction for age and levels of low-density lipoprotein cholesterol. However, levels of heparin-releasable free FL TFPI were higher in patients than in controls. Conclusions: Although ambient plasma levels of total TFPI were not different in subtypes of LS, the increased levels of heparin-releasable TFPI in patients suggest a role of endothelial activation in the pathogenesis of LS. Neurology (R) 2012;78:493-498 |
| Databáze: | OpenAIRE |
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