Depression and BMI influences the serum vascular endothelial growth factor level
| Autor: | Betina Elfving, Anders D. Børglum, Linda Kaerlev, Gregers Wegener, Sigurd Mikkelsen, Matias Brødsgaard Grynderup, Henrik A Kolstad, Leslie Foldager, Pia Haun Poulsen, Ole Mors, Åse Marie Hansen, Henriette N. Buttenschøn |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Vascular Endothelial Growth Factor A medicine.medical_specialty Genotype medicine.medical_treatment Single-nucleotide polymorphism Polymorphism Single Nucleotide vascular endothelial growth factor (VEGF) Statistics Nonparametric Body Mass Index Pathogenesis chemistry.chemical_compound Age single nucleotide polymorphism (SNP) Internal medicine medicine Humans body mass index (BMI) Pharmacology (medical) Depression (differential diagnoses) Genetic Association Studies Retrospective Studies Pharmacology business.industry Depression Middle Aged Vascular endothelial growth factor Psychiatry and Mental health Vascular endothelial growth factor A Cytokine Endocrinology chemistry Genetic marker depression Female business Body mass index |
| Zdroj: | Elfving, B, Buttenschøn, H N, Foldager, L, Poulsen, P H P, Grynderup, M B, Hansen, A M, Kolstad, H A, Kaerlev, L, Mikkelsen, S, Børglum, A D, Wegener, G & Mors, O 2014, ' Depression and BMI influences the serum vascular endothelial growth factor level ', International Journal of Neuropsychopharmacology, vol. 17, no. 9, pp. 1409-1417 . https://doi.org/10.1017/S1461145714000273 Elfving, B, Buttenschøn, H N, Foldager, L, Poulsen, P H P, Grynderup, M B, Hansen, Å M, Kolstad, H A, Kaerlev, L, Mikkelsen, S, Børglum, A D, Wegener, G & Mors, O 2014, ' Depression and BMI influences the serum vascular endothelial growth factor level ', International Journal of Neuropsychopharmacology, vol. 17, no. 9, pp. 1409-1417 . https://doi.org/10.1017/S1461145714000273 |
| Popis: | Recent studies suggest that the angiogenic cytokine vascular endothelial growth factor (VEGF) is involved in the pathogenesis of depression. However, only a few studies have investigated serum VEGF levels in individuals with depression, or the possible association between genetic variants within the VEGF gene and depression. The purpose of the present study was to investigate differences between serum VEGF levels in individuals with depression vs. control individuals, and associations between genetic markers located within VEGF and depression. In addition, determinants of the serum VEGF levels were identified. One-hundred and fifty-five depressed subjects and 280 controls were included in the study. All individuals returned a questionnaire and participated in a semi-structured diagnostic interview. Eleven single nucleotide polymorphisms were successfully analysed. VEGF levels were measured in serum by immunoassay and independent determinants of the serum VEGF level were assessed by generalized linear models.The main findings were that depression, severity of depression, previous depressive episodes, age and body mass index (BMI) were associated with higher serum VEGF levels. The genetic marker rs10434 was significantly associated with depression after correction for multiple testing, but not with the serum VEGF level. Our final model included depression and BMI as predictors of serum VEGF levels. Our study suggests a role for circulating serum VEGF in depression. Furthermore, our data also demonstrate that other factors than a diagnosis of depression influence the serum VEGF level. The importance of these factors should be emphasized when studies are compared. |
| Databáze: | OpenAIRE |
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