Synthesis of α,α-Difluoromethylene Alkynes by Palladium-Catalyzedgem-Difluoropropargylation of Aryl and Alkenyl Boron Reagents
Autor: | Yanbo Yu, Xingang Zhang, Guo-Zhen He |
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Rok vydání: | 2014 |
Předmět: | |
Zdroj: | Angewandte Chemie. 126:10625-10629 |
ISSN: | 0044-8249 |
DOI: | 10.1002/ange.201405204 |
Popis: | gem-Difluoropropargyl bromides are versatile intermediates in organic synthesis, but have rarely been employed in transition-metal-catalyzed cross-coupling reactions. The first palladium-catalyzed gem-difluoropropargylation of organoboron reagents with gem-difluoropropargyl bromides is now reported. The reaction proceeds under mild reaction conditions with high regioselectivity; it features a broad substrate scope and excellent functional-group compatibility and thus provides an attractive approach for the synthesis of complex fluorinated molecules, in particular for drug discovery and development. |
Databáze: | OpenAIRE |
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