The influence of vitamin E on capsule formation and contracture around silicone implants
| Autor: | T E Shaw, C R Peters, D R Raju |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Biometry Contracture Croton Oil medicine.medical_treatment Administration Topical Anti-Inflammatory Agents Prosthesis Injections Intramuscular chemistry.chemical_compound Silicone medicine Pressure Animals Vitamin E Croton oil Skin Back Ocular micrometer business.industry Foreign-Body Reaction Muscles Prostheses and Implants medicine.disease Surgery Rats chemistry Silicone Elastomers medicine.symptom Foreign body business Capsule formation |
| Zdroj: | Annals of plastic surgery. 5(5) |
| ISSN: | 0148-7043 |
| Popis: | An attempt was made to determine if the tissue response to surgical trauma and foreign body stimulus (silicone implants) could be altered using vitamin E in rats. The animals were divided into four groups: Group A served as controls, Group B were treated by intramuscular vitamin E, Group C were treated topically with vitamin E around the prosthesis, and Group D were treated topically with croton oil around the prosthesis. The animals in each group were killed at 2 week, 1 month, and 3 months intervals. The intraprosthetic pressure in each prosthesis was recorded using a strain gauge transducer. The capsules were then removed and examined histologically using a light microscope and the thickness of pseudocapsules was measured with an ocular micrometer. In Group B significantly thinner pseudocapsules were observed at 2 weeks, but there was no comparable difference either in thickness or degree of contracture (as measured by intraprosthetic pressures) between Groups A and B at 2 months and 3 months. In Group C, the pseudocapsules were significantly thicker at all tested periods and showed noticeable contracture at 3 months. In group D the pseudocapsules were thickest and cellular infiltrate more marked than in the other groups. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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