Tctex-1 augments G protein-coupled receptor-mediated Gs signaling by activating adenylyl cyclase
| Autor: | Ayano Chiba, Norimichi Nakahata, Takahiro Moriya, Jun Sukegawa, Masaki Saito, Takeya Sato |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pharmacology Parathyroid hormone receptor Mechanism (biology) Cytoplasmic dynein light chain Tctex-1 lcsh:RM1-950 Cell biology Adenylyl cyclase 03 medical and health sciences chemistry.chemical_compound lcsh:Therapeutics. Pharmacology 030104 developmental biology 0302 clinical medicine chemistry Molecular Medicine Signal transduction Receptor 030217 neurology & neurosurgery G protein-coupled receptor |
| Zdroj: | Journal of Pharmacological Sciences, Vol 145, Iss 1, Pp 150-154 (2021) |
| ISSN: | 1347-8613 |
| DOI: | 10.1016/j.jphs.2020.11.011 |
| Popis: | Proteins interacting with G protein-coupled receptors (GPCRs) can modulate signal transduction of these receptors. However, the regulatory mechanisms of the interacting proteins are diverse and largely unknown. We have previously shown that Tctex-1 (or DYNLT1) can interact with the parathyroid hormone receptor (PTHR). In the present study, we investigated the role of Tctex-1 in the PTHR signaling and found that Tctex-1 augmented the PTHR-mediated Gs/adenylyl cyclase (AC) pathway by activating AC regardless of the binding to PTHR. Furthermore, Tctex-1 directly bound to AC type 6. These data demonstrate a novel mechanism underlying GPCR/Gs signaling regulated by Tctex-1. |
| Databáze: | OpenAIRE |
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