Effect of Bendroflumethiazide on Na+ and Ca++ Transport in Rat and Guinea Pig Jejunum
| Autor: | J. Rask–Madsen, F. Schønau Jørgensen |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Male
Absorption (pharmacology) medicine.medical_specialty Cell Membrane Permeability Cell membrane permeability Guinea Pigs Biological Transport Active Toxicology Jejunum Guinea pig Internal medicine medicine Animals Bendroflumethiazide Intestinal Mucosa Thiazide Pharmacology Membrane potential Ca metabolism Chemistry Sodium Rats Endocrinology medicine.anatomical_structure Intestinal Absorption Calcium medicine.drug |
| Zdroj: | Acta Pharmacologica et Toxicologica. 39:1-6 |
| ISSN: | 0001-6683 |
| Popis: | The effect of therapeutic bendroflumethiazide (BHFT) concentrations on transepithelial Na+ and Ca++ transport in the rat and guinea pig jejunum was studied by the Ussing technique. In the rat a relative depression of Na+ and Ca++ fluxes from the mucosa to serosa as well as a relative increase of the opposite Na+ flux was observed. These effects suggest an inhibition of BHFT on Na+ and Ca++ absorption, which may prevent the development of a positive Ca++ balance during long–term thiazide administration. No consistent changes were found in the guinea pig – either in Na+ or in Ca++ transport. |
| Databáze: | OpenAIRE |
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