New Insights into Cancer Targeted Therapy: Nodal and Cripto-1 as Attractive Candidates

Autor: Paola Arboretto, Antonio Leonardi, Michele Cillo
Přispěvatelé: Arboretto, P., Cillo, M., Leonardi, A.
Rok vydání: 2021
Předmět:
0301 basic medicine
Cellular differentiation
medicine.medical_treatment
Proliferation
Nodal
Review
therapeutic targets
Cripto
medicine.disease_cause
Targeted therapy
Antineoplastic Agent
0302 clinical medicine
Neoplasms
Molecular Targeted Therapy
Biology (General)
Spectroscopy
General Medicine
GPI-Linked Protein
Computer Science Applications
Chemistry
030220 oncology & carcinogenesis
Human
QH301-705.5
Therapeutic target
Nodal Protein
Antineoplastic Agents
Biology
GPI-Linked Proteins
Catalysis
Inorganic Chemistry
03 medical and health sciences
Cancer stem cell
medicine
Animals
Humans
Physical and Theoretical Chemistry
QD1-999
Molecular Biology
Animal
Organic Chemistry
Cancer
Biomarker
medicine.disease
Cripto-1
030104 developmental biology
Tumor progression
Drug resistance
Cancer cell
Cancer research
Neoplasm
Carcinogenesis
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 22, Iss 7838, p 7838 (2021)
ISSN: 1422-0067
DOI: 10.3390/ijms22157838
Popis: The transforming growth factor beta (TGF-β) signaling is fundamental for correct embryonic development. However, alterations of this pathway have been correlated with oncogenesis, tumor progression and sustaining of cancer stem cells (CSCs). Cripto-1 (CR-1) and Nodal are two embryonic proteins involved in TGF-β signaling. Their expression is almost undetectable in terminally differentiated cells, but they are often re-expressed in tumor cells, especially in CSCs. Moreover, cancer cells that show high levels of CR-1 and/or Nodal display more aggressive phenotypes in vitro, while in vivo their expression correlates with a worse prognosis in several human cancers. The ability to target CSCs still represents an unmet medical need for the complete eradication of certain types of tumors. Given the prognostic role and the selective expression of CR-1 and Nodal on cancer cells, they represent archetypes for targeted therapy. The aim of this review is to clarify the role of CR-1 and Nodal in cancer stem populations and to summarize the current therapeutic strategy to target CSCs using monoclonal antibodies (mAbs) or other molecular tools to interfere with these two proteins.
Databáze: OpenAIRE
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