LEM domain containing 1 promotes oral squamous cell carcinoma invasion and endothelial transmigration
Autor: | Tomonori Sasahira, Tadaaki Kirita, Hiroki Kuniyasu, Miyako Kurihara, Chie Nakashima |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
0301 basic medicine
transendothelial migration Adult Male Cancer Research Pathology medicine.medical_specialty LEMD1 Cell Down-Regulation Disease-Free Survival 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Cell Line Tumor Carcinoma medicine Humans Molecular Diagnostics Aged Mouth neoplasm Aged 80 and over Gene knockdown business.industry Transendothelial and Transepithelial Migration oral cancer Middle Aged medicine.disease Prognosis Neoplasm Proteins stomatognathic diseases 030104 developmental biology Lymphatic system medicine.anatomical_structure Oncology nodal metastasis 030220 oncology & carcinogenesis Lymphatic Metastasis Cancer cell Carcinoma Squamous Cell Disease Progression Immunohistochemistry Female Mouth Neoplasms business |
Zdroj: | British Journal of Cancer |
ISSN: | 1532-1827 0007-0920 |
Popis: | Background: Oral squamous cell carcinomas have high potential for locoregional invasion and nodal metastasis. Thus, early detection and elucidation of detailed molecular mechanisms of OSCCs are important. Roles of LEM domain containing 1 (LEMD1), a novel cancer–testis antigen, in OSCCs are unclear. Methods: We performed immunohistochemical analysis of LEMD1 in 289 OSCC patients and examined functions of LEMD1 in these carcinomas. Results: Immunohistochemical analysis showed that 101 patients were positive for LEMD1. LEM domain containing 1 expression levels in OSCCs significantly correlated with tumour progression (T factor and clinical stage), nodal metastasis, and poor prognosis. LEM domain containing 1 expression was an independent predictor of disease-free survival in OSCC patients. In OSCCs, LEMD1 knockdown suppressed cancer cell invasion. Moreover, downregulation of LEMD1 expression inhibited adhesion and transmigration of OSCCs and vascular or lymphatic vascular endothelial cells. Conclusions: Our findings suggest that LEMD1 is a novel tumour progressive factor and may be a useful diagnostic and therapeutic target in OSCCs. |
Databáze: | OpenAIRE |
Externí odkaz: |