Plasma Free Amino Acid Responses to Whey Protein and Their Relationships with Gastric Emptying, Blood Glucose- and Appetite-Regulatory Hormones and Energy Intake in Lean Healthy Men
| Autor: | Kylie Lange, Michael Horowitz, Christine Feinle-Bisset, Amy T. Hutchison, Rachel A. Elovaris, Natalie D. Luscombe-Marsh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Whey protein Time Factors 030309 nutrition & dietetics medicine.medical_treatment Peptide Hormones Whey protein isolate 0302 clinical medicine South Australia branched-chain amino acids Amino Acids media_common 0303 health sciences Nutrition and Dietetics Cross-Over Studies biology Chemistry digestive oral and skin physiology Healthy Volunteers 3. Good health cholecystokinin Ghrelin lcsh:Nutrition. Foods and food supply hormones hormone substitutes and hormone antagonists Adult medicine.medical_specialty Adolescent media_common.quotation_subject lcsh:TX341-641 030209 endocrinology & metabolism Glucagon Article 03 medical and health sciences Young Adult Double-Blind Method Internal medicine medicine Humans human Gastric emptying Appetite Regulation Insulin Appetite Endocrinology Whey Proteins glucagon-like peptide-1 glucagon Gastric Emptying biology.protein dairy Energy Intake Biomarkers Food Science Hormone |
| Zdroj: | Nutrients Volume 11 Issue 10 Nutrients, Vol 11, Iss 10, p 2465 (2019) |
| ISSN: | 2072-6643 |
| Popis: | This study determined the effects of increasing loads of whey protein on plasma amino acid (AA) concentrations, and their relationships with gastric emptying, blood glucose- and appetite-regulatory hormones, blood glucose and energy intake. Eighteen healthy lean men participated in a double-blinded study, in which they consumed, on 3 separate occasions, in randomised order, 450-mL drinks containing either 30 g (L) or 70 g (H) of pure whey protein isolate, or control with 0 g of protein (C). Gastric emptying, serum concentrations of AAs, ghrelin, cholecystokinin (CCK), glucagon-like-peptide 1 (GLP-1), insulin, glucagon and blood glucose were measured before and after the drinks over 180 min. Then energy intake was quantified. All AAs were increased, and 7/20 AAs were increased more by H than L. Incremental areas under the curve (iAUC0–180 min) for CCK, GLP-1, insulin and glucagon were correlated positively with iAUCs of 19/20 AAs (p < 0.05). The strongest correlations were with the branched-chain AAs as well as lysine, tyrosine, methionine, tryptophan, and aspartic acid (all R2 > 0.52, p < 0.05). Blood glucose did not correlate with any AA (all p > 0.05). Ghrelin and energy intake correlated inversely, but only weakly, with 15/20 AAs (all R2 < 0.34, p < 0.05). There is a strong relationship between gluco-regulatory hormones with a number of (predominantly essential) AAs. However, the factors mediating the effects of protein on blood glucose and energy intake are likely to be multifactorial. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|