Endotoxin Effects on Markers of Autonomic Nervous System Function in the Piglet: Implications for SIDS
| Autor: | Logan J. Voss, Barry J Taylor, D P G Bolton, Barbara C. Galland |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
Nitroprusside medicine.medical_specialty Swine Blood Pressure Biology Baroreflex Autonomic Nervous System Phenylephrine Bolus (medicine) Heart Rate Salmonella Internal medicine Heart rate medicine Animals Humans Heart rate variability Infant Newborn Sudden infant death syndrome Endotoxins Autonomic nervous system Blood pressure Endocrinology Animals Newborn Pediatrics Perinatology and Child Health Female Sudden Infant Death Body Temperature Regulation Developmental Biology medicine.drug |
| Zdroj: | Neonatology. 86:39-47 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000077452 |
| Popis: | The hypothesis was tested in 30 newborn piglets that the effects of a low dose of endotoxin (1 µg i.v. bolus; Salmonella abortus equi) would impair autonomic nervous system function. Two tests of autonomic function were performed following external warming (pre-endotoxin) and during endotoxin-generated thermogenesis: (1) analysis of heart rate variability in the time and frequency domains and (2) baroreflex sensitivity measured following intravenous injection of the vasoactive drugs nitroprusside and phenylephrine. Beat-to-beat heart rate variability (SDΔRR) fell by 2.2 ms from 7.0 ms before fever (p < 0.05). Low-frequency spectral power fell by 2.4 ms2 from 4.1 ms2 before fever (p < 0.05). The sensitivity of the baroreflex to changes in blood pressure induced by the vasoactive drugs decreased during fever by 0.72 ms/mm Hg for the nitroprusside test (p < 0.0005) and by 0.31 ms/mm Hg for the phenylephrine test (p < 0.005). These results indicate that in the piglet the balance of autonomic tone is altered and autonomic responsiveness reduced during the thermogenic phase of a fever. These findings are consistent with known risk factors for sudden infant death syndrome. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|