Synthesis, XRD, HAS, in silico molecular docking studies and biological assessment of novel Schiff base compounds as anti-cancer and antimicrobial agents
Autor: | Nahla Bouqellah, Mani Shanmugam, Wael S. Al-Harbi, Faizah S. Aljohani, Nadia S. Al-Kaff, Musa A. Said |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
crystal structure
Science (General) In silico schiff bases (sb) 02 engineering and technology 01 natural sciences 010305 fluids & plasmas chemistry.chemical_compound Q1-390 0103 physical sciences hirshfeld surface analysis medicine Cytotoxicity anti-cancer enol-imine tautomeric form Schiff base antimicrobial activity Cancer docking studies 021001 nanoscience & nanotechnology medicine.disease Antimicrobial Combinatorial chemistry In vitro chemistry cytotoxicity 0210 nano-technology |
Zdroj: | Journal of Taibah University for Science, Vol 14, Iss 1, Pp 1590-1603 (2020) |
ISSN: | 1658-3655 |
Popis: | In this study, versatile multifunctional Schiff base (SB) derivatives were synthesized. Compounds 1–8 were prepared by a mild condition and were pharmacologically assessed for their role in vitro anti-cancer and their impact on human fibrosarcoma (HT-1080) and cervical cancer cells (HeLa), in addition to their antimicrobial activity regarding fungal strains, gram-positive and gram-negative bacteria. Preliminary in silico study of 1–8 and the standard compound (5-Fluorouracil) was accomplished, using Drug2Way and PASS software. Besides, docking investigations were carried out using Schrödinger software to determine the interaction of p53-MDM2 and pf-DHFR binding affinity for all the compounds. The antimicrobial results exhibited that these novel compounds have modest to good inhibitory action against the tried bacterial and fungal strains. The crystal structures of 2 and 7 have been determined. Hirshfeld Surface Analysis (HSA) is in agreement with the XRD studies. Both compounds have shown enol–imine tautomeric forms as EE isomer. |
Databáze: | OpenAIRE |
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