Apical stress fibers enable a scaling between cell mechanical response and area in epithelial tissue
| Autor: | Hayden Nunley, Boris Guirao, David K. Lubensky, Meryl A. Spencer, Yohanns Bellaïche, Stéphane Pelletier, Isabelle Gaugue, Jesús M. López-Gay, Floris Bosveld, Florencia di Pietro, Olga Markova |
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| Přispěvatelé: | Génétique et Biologie du Développement, Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Polarity Division and Morphogenesis, Institut Curie, CNRS UMR 3215, INSERM U934, 75248 Paris Cedex 05, France, Centre National de la Recherche Scientifique (CNRS)-Institut Curie [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2020 |
| Předmět: |
[SDV]Life Sciences [q-bio]
Cell Protein Serine-Threonine Kinases Mechanotransduction Cellular Epithelium Stress (mechanics) Adherens junction 03 medical and health sciences 0302 clinical medicine Stress Fibers medicine Animals Drosophila Proteins Mechanotransduction ComputingMilieux_MISCELLANEOUS Cell Size 030304 developmental biology Myosin Type II 0303 health sciences Hippo signaling pathway Multidisciplinary biology Chemistry Intracellular Signaling Peptides and Proteins Nuclear Proteins Epithelial Cells YAP-Signaling Proteins Cadherins biology.organism_classification Cell biology Drosophila melanogaster medicine.anatomical_structure Hippo signaling Trans-Activators Stress Mechanical 030217 neurology & neurosurgery |
| Zdroj: | Science Science, AAAS, 2020, ⟨10.1126/science.abb2169⟩ Science, American Association for the Advancement of Science, 2020, 370 (6514), pp.eabb2169. ⟨10.1126/science.abb2169⟩ |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.abb2169 |
| Popis: | Biological systems tailor their properties and behavior to their size throughout development and in numerous aspects of physiology. However, such size scaling remains poorly understood as it applies to cell mechanics and mechanosensing. By examining how the Drosophila pupal dorsal thorax epithelium responds to morphogenetic forces, we found that the number of apical stress fibers (aSFs) anchored to adherens junctions scales with cell apical area to limit larger cell elongation under mechanical stress. aSFs cluster Hippo pathway components, thereby scaling Hippo signaling and proliferation with area. This scaling is promoted by tricellular junctions mediating an increase in aSF nucleation rate and lifetime in larger cells. Development, homeostasis, and repair entail epithelial cell size changes driven by mechanical forces; our work highlights how, in turn, mechanosensitivity scales with cell size. |
| Databáze: | OpenAIRE |
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