Postischemic Microcirculatory Blood Flow Correlates Negatively and Independently With Plasma C-Reactive Protein in Longstanding Type 1 Diabetes
| Autor: | Gerald F. Watts, Ben Turner, James Gibney, Michael H. Cummings, Daryl R. Meeking, U. Weis, Ken M. Shaw, Jane Cansfield |
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| Rok vydání: | 2002 |
| Předmět: |
medicine.medical_specialty
Time Factors Endocrinology Diabetes and Metabolism Inflammation Systemic inflammation Ischemia Internal medicine Diabetes mellitus Internal Medicine medicine Humans Endothelial dysfunction Reactive hyperemia Advanced and Specialized Nursing Type 1 diabetes business.industry Microcirculation Acute-phase protein Blood flow Middle Aged medicine.disease Forearm C-Reactive Protein Cross-Sectional Studies Diabetes Mellitus Type 1 Endocrinology Regional Blood Flow medicine.symptom business Blood Flow Velocity Diabetic Angiopathies |
| Zdroj: | Diabetes Care. 25:802-803 |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/diacare.25.4.802 |
| Popis: | Moderately increased plasma C-reactive protein (CRP), an acute phase protein produced by the liver and an exquisitely sensitive marker of inflammation, is associated with an increased risk of cardiovascular disease (1). It is not known how systemic inflammation leads to atherosclerosis, but experimental (2) and clinical (3) studies have suggested that it may do so by causing endothelial dysfunction, a process central to the development of atherosclerosis. Reactive hyperemia (RH) is an endothelium-dependent, physiological, and probably protective response to tissue ischemia that is reduced in patients with atherosclerosis or risk factors for atherosclerosis. The forearm vascular bed, which is readily accessible and rarely affected by atheromatous change, is a useful site to study RH using noninvasive techniques. A close relationship has been shown between coronary endothelial function and RH in the human … |
| Databáze: | OpenAIRE |
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