Stable, long-term, spatial memory in young and aged rats achieved with a one day Morris water maze training protocol
| Autor: | Heather M. D'Angelo, Meagan M. Kitt, Jerry W. Rudy, Steven F. Maier, Linda R. Watkins, Ruth M. Barrientos |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Aging medicine.medical_specialty Memory Long-Term Time Factors Cognitive Neuroscience Spatial ability Maze learning Morris water navigation task Audiology Brief Communication 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Age groups Animals Medicine Animal behavior Maze Learning Spatial Memory Psychological Tests Age differences Long-term memory business.industry Rats Inbred F344 030104 developmental biology Neuropsychology and Physiological Psychology business 030217 neurology & neurosurgery |
| Zdroj: | Learning & Memory. 23:699-702 |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.043489.116 |
| Popis: | Here, we present data demonstrating that a 1 d Morris water maze training protocol is effective at producing stable, long-term spatial memory in both young (3 mo old) and aged (24 mo old) F344xBN rats. Four trials in each of four sessions separated by a 2.5 h ISI produced robust selective search for the platform 1 and 4 d after training, in both age groups. A 1 h ISI protocol did not produce good retention. Also, compressing the trials into just two sessions separated by a 2.5 h ISI produced limited retention in only young rats. |
| Databáze: | OpenAIRE |
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