Serum levels of soluble CD30 in chronic hepatitis B virus infection
| Autor: | Giovanna Fattovich, Giuliano Giustina, Giovanni Pizzolo, L. Morosato, Arturo Ruol, Fabrizio Vinante, Alfredo Alberti |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male HBsAg Adolescent Immunology Ki-1 Antigen Review medicine.disease_cause Immune system Antigen medicine Humans Immunology and Allergy Aged Hepatitis Chronic Hepatitis Hepatitis B virus biology business.industry Middle Aged Hepatitis B medicine.disease biology.organism_classification Virology Solubility Hepadnaviridae biology.protein Female Antibody business |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.1996.915607.x |
| Popis: | SUMMARY There is evidence that both cellular and humoral components of the immune response are required for viral clearance to occur in chronic hepatitis B. Recent studies demonstrated that CD30 molecule, a member of the tumour necrosis factor superfamily of membrane cytokine receptors, is expressed on, and released as a soluble molecule (sCD30) by activated T cells producing T helper 2 (Th2) cytokines, which modulate antibody responses. To better characterize the immunoregulatory mechanisms in chronic hepatitis B virus (HBV) infection, sCD30 values were evaluated by an ELISA in 90 hepatitis B surface (HBsAg)-positive patients with chronic hepatitis, selected on the basis of active viral replication and biochemical activity. At presentation abnormal levels (>20 U/ml) of sCD30 were detected in 57 (63%) out of 90 patients with chronic hepatitis B, and median value was significantly higher in this group of patients compared with that of healthy HBsAg carriers (26.7 versus 10.5 U/ml, P |
| Databáze: | OpenAIRE |
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