HPV-related Sinonasal Carcinoma
| Autor: | Rina Jiromaru, Takahiro Hongo, Takashi Nakagawa, Yui Nozaki, Kazuki Hashimoto, Muneyuki Masuda, Yoshinao Oda, Kenichi Taguchi, Hidetaka Yamamoto, Ryuji Yasumatsu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine DNA Copy Number Variations Chromogenic in situ hybridization In situ hybridization Retinoblastoma Protein Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Biomarkers Tumor Carcinoma Humans Medicine Copy-number variation Epidermal growth factor receptor EGFR Protein Overexpression Cyclin-Dependent Kinase Inhibitor p16 Aged Retrospective Studies Aged 80 and over biology business.industry Genes p16 Papillomavirus Infections HPV infection Reproducibility of Results virus diseases Middle Aged Prognosis medicine.disease Immunohistochemistry ErbB Receptors Gene Expression Regulation Neoplastic 030104 developmental biology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Cancer research biology.protein Female Surgery Anatomy business Paranasal Sinus Neoplasms Follow-Up Studies |
| Zdroj: | American Journal of Surgical Pathology. 44:305-315 |
| ISSN: | 0147-5185 |
| Popis: | The prevalence and prognostic value of human papillomavirus (HPV) infection and epidermal growth factor receptor (EGFR) alteration in sinonasal squamous cell carcinoma (SNSCC) are not known. The reliability of p16 overexpression as a surrogate for HPV infection in SNSCC is also unclear. We investigated the prognostic and diagnostic significances of HPV infection, EGFR alteration, and p16 expression in SNSCC. We analyzed high-risk HPV infection by HPV-RNA in situ hybridization and EGFR gene copy number gain (CNG) by chromogenic in situ hybridization and by determining the protein expressions of p16, Rb, and EGFR by immunohistochemistry in 101 SNSCC cases. HPV infection (n=9, 8.9%) and p16 overexpression (n=15, 14.9%) were associated with better overall survival (P=0.0042 and 0.005, respectively). The HPV cases were located predominantly at the nasal cavity with nonkeratinizing histology and partial loss of Rb. Notably, 40% (6/15) of p16 SNSCCs were HPV. Two of these cases showed complete loss of Rb expression by immunohistochemistry, suggesting a reason for the above discrepancy. EGFR CNG, detected in 30.5% of the SNSCCs, was correlated with EGFR protein overexpression (P=0.0001). HPV infection and EGFR CNG were mutually exclusive. The HPV/EGFR CNG group had significantly better overall survival than the HPV/EGFR CNG and HPV/EGFR CNG groups (P=0.0471 and 0.0343, respectively). Our results suggest that HPV infection is a favorable prognostic marker in SNSCC, but p16 is not a perfect surrogate marker; the Rb expression pattern may improve the diagnostic accuracy. The molecular subclassification of SNSCCs based on HPV infection and EGFR copy number status might provide important information for therapeutic strategies. |
| Databáze: | OpenAIRE |
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