Biopolymer‐based Carriers for DNA Vaccine Design
| Autor: | Ljiljana Fruk, Christoph O. Franck, Andrea Bistrovic Popov, Luise Fanslau, Puneet Tyagi |
|---|---|
| Přispěvatelé: | Fruk, Ljiljana [0000-0003-2104-5817], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
32 Biomedical and Clinical Sciences biopolymers Review FOS: Health sciences 01 natural sciences chemistry.chemical_compound Neoplasms Vaccines DNA Vaccines Immunogenicity Antibodies Monoclonal 3 Good Health and Well Being General Medicine Hepatitis B Vaccination 3204 Immunology Infectious Diseases 3.4 Vaccines Virus Diseases immunotherapy Infection Biotechnology nanostructure Reviews Context (language use) Gene delivery Biology 010402 general chemistry Catalysis DNA vaccination DNA vaccines Vaccine Related medicine Genetics Humans gene delivery 010405 organic chemistry Prevention General Chemistry Immunotherapy medicine.disease Virology 0104 chemical sciences chemistry FOS: Biological sciences Liposomes Immunization DNA T-Lymphocytes Cytotoxic 3 Prevention of disease and conditions and promotion of well-being |
| Zdroj: | Angewandte Chemie (International Ed. in English) |
| Popis: | Over the last 30 years, genetically engineered DNA has been tested as novel vaccination strategy against various diseases, including human immunodeficiency virus (HIV), hepatitis B, several parasites, and cancers. However, the clinical breakthrough of the technique is confined by the low transfection efficacy and immunogenicity of the employed vaccines. Therefore, carrier materials were designed to prevent the rapid degradation and systemic clearance of DNA in the body. In this context, biopolymers are a particularly promising DNA vaccine carrier platform due to their beneficial biochemical and physical characteristics, including biocompatibility, stability, and low toxicity. This article reviews the applications, fabrication, and modification of biopolymers as carrier medium for genetic vaccines. Recently, the first genetic vaccine has been approved to tackle the COVID‐19 pandemic. Despite their favourable properties, low transfection efficacies prevent many nucleic acid vaccines from being approved for human use. This Review explores strategies that use biopolymeric delivery systems to improve the efficacy of DNA immunisation. |
| Databáze: | OpenAIRE |
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