Autor: |
Ieva Sutkeviciute, X.E. Zhou, Karsten Melcher, Thomas J. Gardella, Alex D. White, Lisa J. Clark, C. Li, Ming-Wei Wang, Shanshan Ma, H.E. Xu, Yan Zhang, Xiaoqing Cai, Li Zhao, D.-D. Shen, Jean-Pierre Vilardaga, Yanyong Kang, Chuankui Li, Tomoyuki Watanabe, Yi Jiang, D. Yang, P.W. de Waal, Frederic Jean-Alphonse, Antao Dai, Jianmin Chen |
Přispěvatelé: |
Chinese Academy of Science (CAS), University of Chinese Academy of Sciences [Beijing] (UCAS), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE) |
Rok vydání: |
2019 |
Předmět: |
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Zdroj: |
Science Science, American Association for the Advancement of Science, 2019, 364 (6436), pp.148-153. ⟨10.1126/science.aav7942⟩ |
ISSN: |
1095-9203 0036-8075 |
Popis: |
Bone-cell regulation, fleshed out One of many medically relevant G protein–coupled receptors, parathyroid hormone receptor-1 (PTH1R) functions in the control of calcium homeostasis and bone physiology. Zhao et al. used cryo–election microscopy to observe the structure of PTH1R in a complex with a modified form of parathyroid hormone and stimulatory G protein. The structural model helps explain how parathyroid hormone interacts with its receptor and the molecular basis for receptor activation. Science , this issue p. 148 |
Databáze: |
OpenAIRE |
Externí odkaz: |
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