Structure and dynamics of the active human parathyroid hormone receptor-1

Autor:	Ieva Sutkeviciute, X.E. Zhou, Karsten Melcher, Thomas J. Gardella, Alex D. White, Lisa J. Clark, C. Li, Ming-Wei Wang, Shanshan Ma, H.E. Xu, Yan Zhang, Xiaoqing Cai, Li Zhao, D.-D. Shen, Jean-Pierre Vilardaga, Yanyong Kang, Chuankui Li, Tomoyuki Watanabe, Yi Jiang, D. Yang, P.W. de Waal, Frederic Jean-Alphonse, Antao Dai, Jianmin Chen
Přispěvatelé:	Chinese Academy of Science (CAS), University of Chinese Academy of Sciences [Beijing] (UCAS), University of Pittsburgh School of Medicine, Pennsylvania Commonwealth System of Higher Education (PCSHE)
Rok vydání:	2019
Předmět:	G protein Amino Acid Motifs Protein domain Parathyroid hormone Plasma protein binding Article [SDV.BDLR.RS]Life Sciences [q-bio]/Reproductive Biology/Sexual reproduction 03 medical and health sciences 0302 clinical medicine Protein Domains [SDV.BC.IC]Life Sciences [q-bio]/Cellular Biology/Cell Behavior [q-bio.CB] Humans Receptor Receptor Parathyroid Hormone Type 1 030304 developmental biology 0303 health sciences Multidisciplinary Chemistry Cryoelectron Microscopy [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular biology [SDV.BBM.MN]Life Sciences [q-bio]/Biochemistry Molecular Biology/Molecular Networks [q-bio.MN] Transmembrane domain Parathyroid Hormone Hormone receptor Helix [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology Biophysics 030217 neurology & neurosurgery Protein Binding
Zdroj:	Science Science, American Association for the Advancement of Science, 2019, 364 (6436), pp.148-153. ⟨10.1126/science.aav7942⟩
ISSN:	1095-9203 0036-8075
Popis:	Bone-cell regulation, fleshed out One of many medically relevant G protein–coupled receptors, parathyroid hormone receptor-1 (PTH1R) functions in the control of calcium homeostasis and bone physiology. Zhao et al. used cryo–election microscopy to observe the structure of PTH1R in a complex with a modified form of parathyroid hormone and stimulatory G protein. The structural model helps explain how parathyroid hormone interacts with its receptor and the molecular basis for receptor activation. Science , this issue p. 148
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ba412c189cb6c87d18a825e085eaff https://doi.org/10.1126/science.aav7942 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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