Effects of radiotherapy for brain metastases on quality of life (QoL). Prospective pilot study of the DEGRO QoL working party
| Autor: | Tobias Bölling, Frank Bruns, Christof Schäfer, Dirk Vordermark, Hans-Joachim Wypior, Susanne Sehlen, Matthias Hipp, Anja Bayerl, Diana Steinmann, Juliane Hagg, Hans Geinitz, Birgitt van Oorschot |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Weakness medicine.medical_specialty Palliative care medicine.medical_treatment Pilot Projects Physical function Risk Assessment Quality of life Palliative radiotherapy Risk Factors Germany medicine Humans Radiology Nuclear Medicine and imaging Longitudinal Studies Aged Aged 80 and over business.industry Brain Neoplasms Incidence Middle Aged medicine.disease Survival Analysis humanities Radiation therapy Survival Rate Hair loss Treatment Outcome Oncology Physical therapy Quality of Life Female Headaches medicine.symptom Radiotherapy Conformal business |
| Zdroj: | Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]. 185(3) |
| ISSN: | 1439-099X |
| Popis: | Prospective data on quality-of-life (QoL) effects of radiotherapy for brain metastases are currently lacking, but would be of great interest to guide therapeutic decisions.From 01/2007 to 08/2007, 46 patients with previously untreated brain metastases were recruited at eight centers. QoL was measured at start of treatment (T(0)) and at 3 months (T(3mo)). In the pilot study, two combinations of QoL instruments could be used at the discretion of the centers (A: EORTC QLQ-C30 and B: EORTC QLQ-C15-PAL both with brain module BN20, assessment by proxies with A: Palliative Care Outcome Scale, B: self-constructed brain-specific instrument).All patients received whole-brain radiotherapy, four with an additional boost irradiation. At T(3mo), 26/46 patients (56.5%) had died. 17/20 survivors (85%) completed the questionnaires. In 3-month survivors, QoL deteriorated in most domains, significant in drowsiness, hair loss and weakness of legs. The scores for headaches and seizures were slightly better after 3 months. Assessment by proxies also suggested worsening of QoL. Initial QoL at T(0) was better in those alive than in those deceased at T(3mo), significant for physical function and for the symptom scales of fatigue and pain, motor dysfunction, communication deficit and weakness of legs.Practicability and compliance appeared better with the (shorter) version B. This version is now used in the ongoing main phase of the study with additional centers. First results indicate a moderate worsening of QoL during the first 3 months after start of palliative radiotherapy for brain metastases. QoL at initiation of radiotherapy may be prognostic for survival. |
| Databáze: | OpenAIRE |
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