Applicability of modified carbon sorbent for removing potentially toxic biologically active molecules of aromatic structure from blood plasma
| Autor: | Natalia Beloborodova, M. L. Getsina, Alexander V. Lavrenov, Anton Ershov, N. V. Kornienko, L. G. P’yanova |
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| Rok vydání: | 2021 |
| Předmět: |
Sorbent
Chemistry 030232 urology & nephrology Biomedical Engineering Prolonged action Medicine (miscellaneous) 030208 emergency & critical care medicine Bioengineering 3-phenyllactic acid Biological activity General Medicine Combinatorial chemistry Carbon Biomaterials Plasma 03 medical and health sciences 0302 clinical medicine Modified carbon Mesoporous carbon Blood plasma Humans Molecule Adsorption |
| Zdroj: | The International Journal of Artificial Organs. 44:930-937 |
| ISSN: | 1724-6040 0391-3988 |
| DOI: | 10.1177/03913988211018478 |
| Popis: | The modification of the mesoporous carbon sorbent with 3-phenylpropanoic acid was carried out in order to create preparations of complex, prolonged action, exhibiting detoxifying, antibacterial, and antifungal properties due to the applied modifier, which is capable of migrating into the solution and exhibiting its own biospecific properties. A technique was developed for fixing 3-phenylpropionic acid (PhPA) on a carbon support by its adsorption from solution. Three types of sorbents with various content of the modifier (PhPA) and the sorbent without modifier were studied. The sorption activity of new sorbents was studied using liquid-liquid extraction and gas chromatography-mass spectrometry methods on model experiments with plasma and aqueous additives of hydroxylated phenyl-containing acids (PhCAs) in various concentrations. The specific surface area was significantly changed for sorbent, modified with 1 × 10−3 mol/L of PhPA solution, and was 25% less than the area of unmodified sorbent. Potentially toxic biologically active hydroxylated PhCAs were used to create model solutions. The degrees of sorption of these compounds were close to 100%, except phenyllactic acid (over 80%). The sorbent without modifier and two sorbents with the lowest content of the modifier are considered to be more effective for the purification of the plasma from the hydroxylated PhCAs than the sorbent with the highest concentration of the modifier. Simultaneous adsorption of toxic metabolites from the bloodstream and desorption of beneficial ones can be used for a more subtle correction of the patient’s condition. |
| Databáze: | OpenAIRE |
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