Branched-Chain Amino Acids as New Biomarkers of Major Depression - A Novel Neurobiology of Mood Disorder

Autor:	Gerhard Reicht, Andreas Meinitzer, Peter Hlade, Harald Mangge, Andreas Baranyi, Omid Amouzadeh-Ghadikolai, Christoph Robier, Hans-Bernd Rothenhäusler, Dirk von Lewinski, Simon Theokas
Rok vydání:	2016
Předmět:	Male 0301 basic medicine Physiology lcsh:Medicine Nervous System Biochemistry 0302 clinical medicine Medicine and Health Sciences Amino Acids lcsh:Science Chromatography High Pressure Liquid Depression (differential diagnoses) Multidisciplinary Depression Organic Compounds TOR Serine-Threonine Kinases Drugs Valine Antidepressants Middle Aged Chemistry Physical Sciences Female Leucine Research Article Adult medicine.medical_specialty Down-Regulation 03 medical and health sciences Internal medicine Mental Health and Psychiatry medicine Humans Isoleucine PI3K/AKT/mTOR pathway Pharmacology Depressive Disorder Major Mood Disorders business.industry lcsh:R Organic Chemistry Chemical Compounds Beck Depression Inventory Case-control study Biology and Life Sciences Proteins Metabolism 030104 developmental biology Endocrinology Mood Aliphatic Amino Acids Case-Control Studies lcsh:Q Energy Metabolism Physiological Processes business Amino Acids Branched-Chain Biomarkers 030217 neurology & neurosurgery
Zdroj:	PLoS ONE PLoS ONE, Vol 11, Iss 8, p e0160542 (2016)
ISSN:	1932-6203
DOI:	10.1371/journal.pone.0160542
Popis:	Background The proteinogenic branched-chain amino acids (BCAAs) valine, leucine and isoleucine might play an unrecognised crucial role in the development of depression through their activation of the mammalian target of rapamycin (mTor) pathway. The aim of this research project is to evaluate whether BCAAs are altered in patients with major depression and might thus be appropriate biomarkers for major depression. Methods The concentrations of valine, leucine and isoleucine were determined in 71 in-patients with major depression and 48 healthy controls by high-pressure liquid chromatography. Psychiatric and laboratory assessments were obtained at the time of in-patient admittance. Results The BCAAs are significantly decreased in patients with major depression in comparison with healthy subjects (valine: Mann-Whitney-U: 968.0; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b4e9002daae0d2311dc64b5a977faf https://doi.org/10.1371/journal.pone.0160542 Zobrazit plný text záznamu