Development of the cortical dysplasia of type II lissencephaly
| Autor: | M. V. Squier |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Histology
Lissencephaly Gestational Age Pathology and Forensic Medicine Cerebellar Cortex Fetus Pregnancy Physiology (medical) medicine Humans Cerebral Cortex business.industry Leptomeninges Infant Newborn Brain Infant Type II lissencephaly Anatomy Cortical dysplasia medicine.disease medicine.anatomical_structure nervous system Neurology Dysplasia Cerebral cortex Gestation Female Neurology (clinical) business Brain Stem |
| Zdroj: | Neuropathology and Applied Neurobiology. 19:209-213 |
| ISSN: | 1365-2990 0305-1846 |
| DOI: | 10.1111/j.1365-2990.1993.tb00430.x |
| Popis: | A detailed neuropathological study of five immature brains with type II lissencephaly is reported. The cases described include two pairs of siblings. One infant survived for 2 months after birth, the others died at 18, 20, 20 and 32 weeks of gestation. This series of cases demonstrates the sequence in which the malformation develops from mid-gestation to post-natal life and shows that type II lissencephaly is not an intracortical malformation but is the result of massive glial and neuronal ectopia in the leptomeninges. This results from a failure of arrest of neuronal migration due to defects in the integrity of the pial/glial barrier. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text