Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells
| Autor: | Matthew J. Stower, Monica Tambalo, Andrea Streit, Katherine E. Trevers, Anna C Strobl, Ravindra Singh Prajapati, Mark Hintze, Natalia Moncaut, Ramya Ranganathan, Mohsin A.F. Khan, Claudio D. Stern |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Central Nervous System
0301 basic medicine animal structures Chick Embryo Biology Mesoderm 03 medical and health sciences 0302 clinical medicine Animals Embryonic Stem Cells In Situ Hybridization Embryonic Induction Neural Plate Multidisciplinary Gene Expression Profiling Gene Expression Regulation Developmental Gastrula Biological Sciences Cell biology Gastrulation Transplantation 030104 developmental biology Neurulation Hypoblast Epiblast embryonic structures Neural plate Neural development 030217 neurology & neurosurgery |
| Zdroj: | Streit, A, Trevers, K, Prajapati, R S, Hintze, M S, Stower, M J, Strobl, A C, Tambalo, M, Ranganathan, R, Moncaut, N, Khan, M A F & Stern, C D 2017, ' Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells ', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, no. 7, pp. 355-360 . https://doi.org/10.1073/pnas.1719674115 |
| DOI: | 10.1073/pnas.1719674115 |
| Popis: | Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes. How different are these processes? Transcriptome analysis in time course reveals that both processes start by induction of a common set of genes, which later diverge. These genes are remarkably similar to those induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrulation stage epiblast. Explants of this epiblast grown in the absence of further signals develop as neural plate border derivatives and eventually express lens markers. We designate this state as "preborder"; its transcriptome resembles embryonic stem cells. Finally, using sequential transplantation experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any of these inductions while the final outcome depends on the tissue emitting the later signals. |
| Databáze: | OpenAIRE |
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