Regional specificity of the gut-incretin response to small intestinal glucose infusion in healthy older subjects
| Autor: | Rachael S. Rigda, Tanya J. Little, Scott Standfield, Christine Feinle-Bisset, Karen L. Jones, Christopher K. Rayner, Tongzhi Wu, Michael Horowitz, Laurence G. Trahair |
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| Přispěvatelé: | Rigda, RS, Trahair, LG, Little, TJ, Wu, T, Standfield, S, Feinle-Bisset, C, Rayner, CK, Horowitz, M, Jones, KL |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood Glucose Male medicine.medical_specialty endocrine system Physiology Duodenum Incretin 030209 endocrinology & metabolism Biology Biochemistry Incretins 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Endocrinology Glucose infusion Glucagon-Like Peptide 1 Internal medicine medicine older subjects Humans Insulin Secretion glucose Glycemic Aged digestive oral and skin physiology Pylorus Glucagon-like peptide-1 Small intestine incretin glucose-dependent insulinotropic polypeptide 030104 developmental biology medicine.anatomical_structure Glucose glucagon-like peptide-1 Organ Specificity Female Cholecystokinin hormones hormone substitutes and hormone antagonists Hormone |
| Zdroj: | Peptides. 86 |
| ISSN: | 1873-5169 |
| Popis: | The importance of the region, as opposed to the length, of small intestine exposed to glucose in determining the secretion of the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) remains unclear. We sought to compare the glycemic, insulinemic and incretin responses to glucose administered to the proximal (12–60 cm beyond the pylorus), or more distal ( > 70 cm beyond the pylorus) small intestine, or both. 10 healthy subjects (9M,1F; aged 70.3 ± 1.4 years) underwent infusion of glucose via a catheter into the proximal (glucose proximally; GP), or distal (glucose distally; GD) small intestine, or both (GPD), on three separate days in a randomised fashion. Blood glucose, serum insulin and plasma GLP-1, GIP and CCK responses were assessed. The iAUC for blood glucose was greater in response to GPD than GP (P < 0.05), with no difference between GD and GP. GP was associated with minimal GLP-1 response (P = 0.05), but substantial increases in GIP, CCK and insulin (P < 0.001 for all). GPD and GD both stimulated GLP-1, GIP, CCK and insulin (P < 0.001 for all). Compared to GP, GPD induced greater GLP-1, GIP and CCK responses (P < 0.05 for all). Compared with GPD, GD was associated with greater GLP-1 (P < 0.05), but reduced GIP and CCK (P < 0.05 for both), responses. We conclude that exposure of glucose to the distal small intestine appears necessary for substantial GLP-1 secretion, while exposure of both the proximal and distal small intestine result in substantial secretion of GIP usc Refereed/Peer-reviewed |
| Databáze: | OpenAIRE |
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