Turner syndrome and osteoporosis
Autor: | Areti Augoulea, Georgia Zachou, Irene Lambrinoudaki |
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Rok vydání: | 2019 |
Předmět: |
Pediatrics
medicine.medical_specialty endocrine system diseases Hormone Replacement Therapy medicine.medical_treatment Osteoporosis Menopause Premature Turner Syndrome Disease Primary Ovarian Insufficiency Short stature Inflammatory bowel disease General Biochemistry Genetics and Molecular Biology vitamin D deficiency Bone and Bones 03 medical and health sciences Fractures Bone 0302 clinical medicine Bone Density Turner syndrome medicine Humans 030212 general & internal medicine X chromosome 030219 obstetrics & reproductive medicine business.industry Obstetrics and Gynecology Hormone replacement therapy (menopause) medicine.disease Inflammatory Bowel Diseases Vitamin D Deficiency Celiac Disease Female medicine.symptom business |
Zdroj: | Maturitas. 130 |
ISSN: | 1873-4111 |
Popis: | Turner syndrome is one of the most common sex chromosomal anomalies, characterized by the complete or partial loss of one X chromosome. Females with Turner syndrome are characterized by skeletal abnormalities, short stature and primary ovarian insufficiency. The aim of this narrative review was to identify the underlying mechanisms of osteoporosis in Turner syndrome, summarize its clinical manifestations and provide suggestions regarding the management of osteoporosis. Girls and women with Turner syndrome have lower bone mineral density and a higher fracture rate than healthy individuals. The most important risk factors for osteoporosis are inadequately treated primary ovarian insufficiency, followed by intrinsic bone abnormalities. Comorbidities that further increase the risk of osteoporosis include vitamin D deficiency, celiac disease and inflammatory bowel disease. In addition, hearing problems can predispose to falls. Early initiation of hormone replacement therapy (HRT) at the age of 11-13 years, prompt titration to the adult dose after 2 years and long-term follow-up to ensure compliance with HRT are the cornerstones of osteoporosis prevention in women with Turner syndrome. |
Databáze: | OpenAIRE |
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