Dietary zeolite supplementation reduces oxidative damage and plaque generation in the brain of an Alzheimer's disease mouse model

Autor: Giuseppina Maccarinelli, Daniela Uberti, Maurizio Memo, Mery Montinaro, Giulia Ferrari-Toninelli, Sara Anna Bonini
Rok vydání: 2013
Předmět:
Male
Mitochondrial ROS
Antioxidant
medicine.medical_treatment
Plaque
Amyloid
Pharmacology
drug therapy/pathology
medicine.disease_cause
Hippocampus
Antioxidants
Transgenic
Mice
Neuroblastoma
General Pharmacology
Toxicology and Pharmaceutics
Plaque
Tumor
Cell Death
biology
Chemistry
Neurodegeneration
Brain
Alzheimer Disease
drug therapy/pathology
Amyloid beta-Peptides
metabolism
Animals
Antioxidants
pharmacology
Brain
drug effects/pathology
Cell Death
Cell Line
Tumor
Dietary Supplements
Disease Models
Animal
Hippocampus
drug effects/metabolism
Humans
Male
Mice
Mice
Transgenic
Neuroblastoma
metabolism
Oxidative Stress
drug effects
Plaque
Amyloid
drug therapy/pathology
Reactive Oxygen Species
metabolism
Superoxide Dismutase
metabolism
Zeolites
pharmacology
General Medicine
Zeolites
Genetically modified mouse
Programmed cell death
Transgene
Mice
Transgenic
General Biochemistry
Genetics and Molecular Biology
Cell Line
Superoxide dismutase
Cell Line
Tumor
medicine
Animals
Humans
Amyloid beta-Peptides
drug effects/pathology
Animal
Superoxide Dismutase
medicine.disease
Disease Models
Animal
Oxidative Stress
drug effects
Dietary Supplements
Disease Models
Immunology
biology.protein
drug effects/metabolism
Reactive Oxygen Species
metabolism
Oxidative stress
Zdroj: Life Sciences. 92:903-910
ISSN: 0024-3205
DOI: 10.1016/j.lfs.2013.03.008
Popis: Aim Oxidative stress is considered one of the main events that lead to aging and neurodegeneration. Antioxidant treatments used to counteract oxidative damage have been associated with a wide variety of side effects or at the utmost to be ineffective. The aim of the present study was to investigate the antioxidant property of a natural mineral, the tribomechanically micronized zeolite (MZ). Main methods Cell death and oxidative stress were assessed in retinoic acid differentiated SH-SY5Y cells, a neuronal-like cell line, after a pro-oxidant stimulus. In vivo evaluation of antioxidant activity and amyloidogenic processing of beta amyloid have been evaluated in a transgenic model of aging related neurodegeneration, the APPswePS1dE9 transgenic mice (tg mice) after a five-month long period of water supplementation with MZ. Key findings The study showed that 24 h of cell pretreatment with MZ (1) protected the cells by radical oxygen species (ROS)-induced cell death and moreover (2) induced a reduction of the mitochondrial ROS production following a pro-oxidant stimulation. Looking for an antioxidant effect of MZ in vivo, we found (3) an increased activity of the endogenous antioxidant enzyme superoxide dismutase (SOD) in the hippocampus of tg mice and (4) a reduction in amyloid levels and plaque load in MZ treated tg mice compared to control tg mice. Significance Our results suggest MZ as a novel potential adjuvant in counteracting oxidative stress and plaque accumulation in the field of neurodegenerative diseases.
Databáze: OpenAIRE
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