Inflammation and Hemostatic Activation may Contribute to Postsurgical Thrombosis in Patients With Bladder Cancer
| Autor: | Jawed Fareed, Eva Wojick, Marcus L. Quek, Melanie Clark, Schuharazad Abro, Debra Hoppensteadt, Güliz A. Barkan |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment 030204 cardiovascular system & hematology Gastroenterology Immunoglobulin G Cystectomy 03 medical and health sciences Postoperative Complications 0302 clinical medicine Cell-Derived Microparticles Internal medicine medicine Humans Retrospective Studies Subclinical infection Inflammation Hemostasis Bladder cancer biology business.industry Cancer Thrombosis Hematology General Medicine medicine.disease Confidence interval Surgery Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Antibodies Antiphospholipid biology.protein Female Antibody business Biomarkers |
| Zdroj: | Clinical and Applied Thrombosis/Hemostasis. 22:314-321 |
| ISSN: | 1938-2723 1076-0296 |
| Popis: | The alterations of the inflammatory and thrombotic components in patients with cancer are not clearly understood. The purpose of this study was to profile markers of inflammation and thrombotic activation specifically in the patients with bladder cancer undergoing radical cystectomy. For this study, 134 samples were collected from patients undergoing radical cystectomy. Antiphospholipid antibodies (immunoglobulin G subtype), microparticles, and antiglycosaminoglycan antibodies were measured with a commercially available enzyme-linked immunosorbent assay kits. These biomarkers were compared in patients with bladder cancer and normal individuals (n = 20). Patients had an average value of 6.7 ± 11.9 ng/mL (median: 2.8, confidence interval: 4.69-8.75, and P value: .0038) of antiphospholipid antibodies versus normal individuals 1.96 ± 0.9 ng/mL (median: 1.8 and confidence interval: 1.5-2.35). Microparticles level in patients was 8.31 ± 6.14 ng/mL, (median: 6.1, confidence interval: 7.26-9.37, and P value |
| Databáze: | OpenAIRE |
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