Genetic Study in a Large Cohort Supported Different Pathogenesis of Graves’ Disease and Hashimoto’s Hypothyroidism
| Autor: | Chun-Lin Zuo, Sha-Sha Yu, Jun Liang, Guan-Qi Gao, Hui-Jun Xie, Zheng Zhou, Huai-Dong Song, Fei-Fei Yuan, Yu-Ru Ma, Wen-Hua Du, Feng Sun, Qian-Yue Zhang, Chang-Run Zhang, Shuang-Xia Zhao, Xiao-Ping Ye, Wei Liu, Lu Li, Guoyue Yuan, Ying-Xia Ying |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Locus (genetics) Single-nucleotide polymorphism Hashimoto Disease 030105 genetics & heredity Biology Polymorphism Single Nucleotide Biochemistry Thyroiditis Receptors G-Protein-Coupled Pathogenesis 03 medical and health sciences Endocrinology Gene Frequency Signaling Lymphocytic Activation Molecule Family Internal medicine medicine Humans CTLA-4 Antigen Genetic Predisposition to Disease Alleles Genetic Association Studies X chromosome Genetic association Biochemistry (medical) Thyroid Middle Aged medicine.disease Graves Disease 030104 developmental biology medicine.anatomical_structure Genetic Loci HLA-B Antigens Female |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 105:e2600-e2608 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Context Hashimoto’s thyroiditis (HT) and Graves’ disease (GD) are the 2 main autoimmune thyroid diseases that have both similarities and differences. Determining the genetic basis that distinguishes HT from GD is key for a better understanding of the differences between these closely related diseases. Objects To identify the susceptibility genes for HT in the Chinese cohort and compare susceptibility genes between GD and HT. Design In the current study, 18 SNPs from 18 established GD risk loci were selected and then genotyped in 2682 patients with HT, 4980 patients with GD, and 3892 controls. The association analysis between HT and controls and heterogeneity analysis between HT and GD were performed on SPSS, with the logistic regression analysis adjusted for sex and age. Results We identified 11 susceptibility loci for HT in the Chinese Han population, with 4 loci, including the rs1265883 in SLAMF6 locus, rs1024161 in CTLA4, rs1521 in HLA-B, and rs5912838 in GPR174/ ITM2A at X chromosome, reaching genome-wide significance of 5 × 10–8. Five loci were reported to be associated with HT for the first time. We also identified 6 susceptibility loci with heterogeneity between GD and HT. Out of them, 4 loci were associated with GD but not with HT, including HLA-DPB1, CD40, TSHR, and TG; the association of HLA-B with GD was stronger than that with HT, but the association of SLAMF6 was reversed. Conclusion Our findings suggested that the pathogenesis of HT and GD was different. |
| Databáze: | OpenAIRE |
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