Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413): A potent human CGRP antagonist with superior safety profile for the treatment of migraine through intranasal delivery
| Autor: | John E. Macor, Chaturvedula Prasad, Rex Denton, Gene M. Dubowchik, Paul Moench, Valerie J. Whiterock, Charlie M. Conway, Cen Xu, Neil Mathias, Glenn H. Cantor, Robert Macci, Richard Schartman, Laura J. Signor, Stephen E. Mercer, George Thalody, Carl D. Davis, Deborah Keavy, Sokhom S. Pin |
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| Rok vydání: | 2013 |
| Předmět: |
Indazoles
medicine.drug_class Migraine Disorders Clinical Biochemistry Drug Evaluation Preclinical Pharmaceutical Science Peptide Carboxamide Respiratory Mucosa Quinolones Calcitonin gene-related peptide Pharmacology Biochemistry chemistry.chemical_compound Calcitonin Gene-Related Peptide Receptor Antagonists Drug Discovery medicine Animals Humans Receptor Molecular Biology Administration Intranasal chemistry.chemical_classification Organic Chemistry Antagonist Callithrix Amides Coronary Vessels Rats chemistry Calcitonin Face Molecular Medicine Nasal administration Rabbits Piperidine Caco-2 Cells Receptors Calcitonin Gene-Related Peptide |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 23:3157-3161 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2013.04.012 |
| Popis: | Calcitonin gene-related peptide (CGRP) receptor antagonists have been shown to be efficacious as abortive migraine therapeutics with the absence of cardiovascular liabilities that are associated with triptans. Herein, we report the discovery of a highly potent CGRP receptor antagonist, BMS-742413, with the potential to provide rapid onset of action through intranasal delivery. The compound displays excellent aqueous solubility, oxidative stability, and toxicological profile. BMS-742413 has good intranasal bioavailability in the rabbit and shows a robust, dose-dependent inhibition of CGRP-induced increases in marmoset facial blood flow. |
| Databáze: | OpenAIRE |
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