Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart

Autor: Vincenzo Cimini, Amelia Filippelli, Guido Iaccarino, Massimo Marchese, Gianfranco Matrone, Carmela Zincarelli, Gennaro Galasso, Luca Golino, Giuseppe Rengo, Francesca Fortunato, Nicola Ferrara, Emma Sanzari, Walter J. Koch, Michele Ciccarelli, Franco Rengo, Giovanna Giuseppina Altobelli, Dario Leosco, Valeria Conti
Přispěvatelé: Leosco, D., Rengo, G., Iaccarino, G., Golino, L., Marchese, M., Fortunato, F., Zincarelli, C., Sanzari, E., Ciccarelli, M., Galasso, G., Altobelli, G. G., Conti, V., Matrone, G., Cimini, V., Ferrara, N., Filippelli, A., Koch, W. J., Rengo, F., Leosco, Dario, Ferrara, Nicola, Rengo, Franco
Rok vydání: 2007
Předmět:
β-adrenergic receptor
Male
Vascular Endothelial Growth Factor A
Time Factors
Heart disease
Physiology
Left
Wistar
Myocardial Infarction
Adrenergic
Nitric Oxide Synthase Type II
Adrenergic beta-Agonists
pharmacology
Animals
Coronary Circulation
Coronary Vessels
drug effects/metabolism/physiopathology
Disease Models
Animal
Dose-Response Relationship
Drug
Heart Failure
etiology/metabolism/physiopathology/ultrasonography
Isoproterenol
pharmacology
Male
Myocardial Contraction
Myocardial Infarction
complications/metabolism/physiopathology/ultrasonography
Myocardium
enzymology/metabolism/pathology
Neovascularization
Physiologic
drug effects
Nitric Oxide Synthase Type II
metabolism
Nitric Oxide Synthase Type III
Physical Exertion
Proto-Oncogene Proteins c-akt
metabolism
Rats
Rats
Wistar
Receptors
beta
drug effects/metabolism
Signal Transduction
drug effects
Time Factors
Vascular Endothelial Growth Factor A
metabolism
Ventricular Function
Left
Ventricular Remodeling
Ventricular Function
Left
Receptors
Medicine
Ventricular Function
Coronary Vessel
Adrenergic beta-Agonist
Ultrasonography
Ventricular Remodeling
etiology/metabolism/physiopathology/ultrasonography
enzymology/metabolism/pathology
Coronary Vessels
Angiogenesi
medicine.anatomical_structure
Drug
Cardiology and Cardiovascular Medicine
Signal Transduction
medicine.medical_specialty
drug effects/metabolism/physiopathology
Time Factor
Nitric Oxide Synthase Type III
Physical Exertion
Neovascularization
Physiologic
Physical exercise
complications/metabolism/physiopathology/ultrasonography
Contractility
Dose-Response Relationship
Exercise training
Coronary circulation
Physiology (medical)
Internal medicine
Coronary Circulation
Receptors
Adrenergic
beta
Animals
Rats
Wistar
Ventricular remodeling
Neovascularization
Heart Failure
Dose-Response Relationship
Drug
business.industry
Animal
Myocardium
Isoproterenol
medicine.disease
Myocardial Contraction
Rats
Disease Models
Animal
Endocrinology
Heart failure
drug effects
Disease Models
Myocardial infarction complications
Rat
pharmacology
Vascular endothelial growth factor
business
drug effects/metabolism
metabolism
Proto-Oncogene Proteins c-akt
Zdroj: Leosco, D, Rengo, G, Iaccarino, G, Golino, L, Marchese, M, Fortunato, F, Zincarelli, C, Sanzari, E, Ciccarelli, M, Galasso, G, Altobelli, G G, Conti, V, Matrone, G, Cimini, V, Ferrara, N, Filippelli, A, Koch, W J & Rengo, F 2007, ' Exercise promotes angiogenesis and improves beta adrenergic receptor signaling in the post-ischemic failing rat heart. ', Cardiovascular Research, vol. 2, no. 78, pp. 385-94 . https://doi.org/10.1093/cvr/cvm109
ISSN: 0008-6363
DOI: 10.1093/cvr/cvm109
Popis: Aims: We investigated whether exercise training could promote angiogenesis and improve blood perfusion and left ventricular (LV) remodelling of the post-myocardial infarction (MI) failing heart. We also explored the contribution of ameliorated beta-adrenergic receptor signalling and function on the overall improvement of cardiac contractility reserve induced by exercise.Methods and results: Adult Wistar male rats were randomly assigned to one of four experimental groups. Sham-operated and post-MI heart failure (HF) rats were housed under sedentary conditions or assigned to 10-weeks of a treadmill exercise protocol. At 4 weeks after MI, sedentary HF rats showed LV eccentric hypertrophy, marked increase of LV diameters associated with severely impaired fractional shortening (14 +/- 5%), increased LV end diastolic pressure (20.9 +/- 2.6 mmHg), and pulmonary congestion. In addition, cardiac contractile responses to adrenergic stimulation were significantly blunted. In trained HF rats, exercise was able to (i) reactivate the cardiac vascular endothelial growth factor pathway with a concurrent enhancement of myocardial angiogenesis, (ii) significantly increase myocardial perfusion and coronary reserve, (iii) reduce cardiac diameters, and (iv) improve LV contractility in response to adrenergic stimulation. This latter finding was also associated with a significant improvement of cardiac beta-adrenergic receptor downregulation and desensitization.Conclusions: Our data indicate that exercise favourably affects angiogenesis and improves LV remodelling and contractility reserve in a rat model of severe chronic HF.
Databáze: OpenAIRE
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