Adipose tissue and breast epithelial cells: a dangerous dynamic duo in breast cancer

Autor: Camille Lehuédé, Béatrice Dirat, Catherine Muller, Ghislaine Escourrou, Philippe Valet, Sophie Le Gonidec, Victor Laurent, Yuan Yuan Wang, Ludivine Bochet, Stéphanie Dauvillier
Přispěvatelé: Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University-Clinical Medical College, Institut de pharmacologie et de biologie structurale (IPBS), Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d'anatomie pathologique et histologie-cytologie [Rangueil], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-CHU Toulouse [Toulouse]-Hôpital de Rangueil, CHU Toulouse [Toulouse], Simon, Marie Francoise, Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Jazyk: angličtina
Rok vydání: 2012
Předmět:
MESH: Signal Transduction
Cancer Research
Pathology
Adipose tissue
MESH: Mammary Glands
Human
0302 clinical medicine
Adipocytes
Medicine
MESH: Obesity
MESH: Animals
0303 health sciences
3. Good health
Cell Transformation
Neoplastic
Oncology
MESH: Adipose Tissue
White
MESH: Epithelial Cells
030220 oncology & carcinogenesis
Disease Progression
Female
MESH: Disease Progression
medicine.symptom
Signal Transduction
medicine.medical_specialty
Cell type
Adipose Tissue
White
Paracrine Communication
Inflammation
Breast Neoplasms
Autologous Fat Transfer
03 medical and health sciences
Breast cancer
Animals
Humans
Obesity
MESH: Paracrine Communication
Progenitor cell
Mammary Glands
Human
MESH: Adipocytes
030304 developmental biology
MESH: Humans
business.industry
Cancer
Epithelial Cells
medicine.disease
MESH: Cell Transformation
Neoplastic
Cancer research
business
MESH: Female
MESH: Breast Neoplasms
Zdroj: Cancer Letters
Cancer Letters, Elsevier, 2012, 324 (2), pp.142-51. ⟨10.1016/j.canlet.2012.05.019⟩
Cancer Letters, 2012, 324 (2), pp.142-51. ⟨10.1016/j.canlet.2012.05.019⟩
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2012.05.019⟩
Popis: International audience; Among the many different cell types surrounding breast cancer cells, the most abundant are those that compose mammary adipose tissue, mainly mature adipocytes and progenitors. New accumulating recent evidences bring the tumor-surrounding adipose tissue into the light as a key component of breast cancer progression. The purpose of this review is to emphasize the role that adipose tissue might play by locally affecting breast cancer cell behavior and subsequent clinical consequences arising from this dialog. Two particular clinical aspects are addressed: obesity that was identified as an independent negative prognostic factor in breast cancer and the oncological safety of autologous fat transfer used in reconstructive surgery for breast cancer patients. This is preceded by the overall description of adipose tissue composition and function with special emphasis on the specificity of adipose depots and the species differences, key experimental aspects that need to be taken in account when cancer is considered.
Databáze: OpenAIRE
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