Delayed diagnosis of congenital thrombotic thrombocytopenic purpura in a patient with recurrent strokes

Autor:	Marina Beltrami-Moreira, Maria T. DeSancho
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Delayed Diagnosis Purpura Thrombotic Thrombocytopenic ADAMTS13 Protein Anemia Thrombosis Hematology Middle Aged Article Congenital thrombotic thrombocytopenia purpura Stroke Cryptogenic recurrent strokes Recurrence hemic and lymphatic diseases Humans Female Cardiology and Cardiovascular Medicine
Zdroj:	Journal of Thrombosis and Thrombolysis
ISSN:	1573-742X 0929-5305
Popis:	Congenital thrombotic thrombocytopenic purpura (cTTP) is caused by ADAMTS13 mutations and associated with high risk of microvascular thrombosis. A 58 year old female had an ischemic stroke during hormonal fertility, and a TIA a year after. She suffered another stroke 18 years later while on warfarin. Four months after she developed severe thrombocytopenia, mild anemia, and increased LDH. Blood film showed schistocytes. She was hospitalized with presumptive TTP. ADAMTS 13 activity was undetectable without inhibitor. She developed another stroke and received plasma exchange. A homozygote ADAMTS 13 mutation was identified. Despite plasma, the ADAMTS13 activity remained
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78aada1260ee38e9897b4b5a6cc0083c http://europepmc.org/articles/PMC8754194 Zobrazit plný text záznamu Full text from SpringerLink