Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejection
| Autor: | Steffen Pelzl, Claudia Sommerer, Peter Schnülle, Constanze Schönemann, Khaled Mahmoud, Gerhard Opelz, Caner Süsal, Volker Daniel, Jan Schmidt, Martin Zeier |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Graft Rejection Male medicine.medical_specialty Pathology Urinary system Biopsy Gastroenterology Internal medicine medicine Humans Transplantation Homologous Acute tubular necrosis Transplantation Kidney Receiver operating characteristic medicine.diagnostic_test business.industry Hepatocyte Growth Factor Middle Aged medicine.disease Kidney Transplantation Liver regeneration medicine.anatomical_structure Health Hepatocyte growth factor Female business Biomarkers medicine.drug |
| Zdroj: | Transplantation. 83(8) |
| ISSN: | 0041-1337 |
| Popis: | Background. It has been shown that hepatocyte growth factor (HGF), besides its well-established hepatotrophic effect in liver regeneration, is involved in the regeneration of the kidney after injury. In the present study we investigated whether HGF can serve as a marker for detection of acute rejection in the early posttransplantation period. Methods. HGF levels were determined in pre- and posttransplant sera (up to day 21) of 26 recipients with biopsyproven acute rejection, 30 recipients with acute tubular necrosis (ATN), and 32 recipients without posttransplant complications. Results. Although no association was found between pretransplant HGF and death-censored functional graft survival, receiver operating characteristic (ROC) curves demonstrated that HGF measured during the entire posttransplant study period, and especially on days 3 to 5, was a good marker for differentiating recipients who subsequently developed acute rejection from recipients with an uncomplicated course (P |
| Databáze: | OpenAIRE |
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