Brain activation during craving for alcohol measured by positron emission tomography
| Autor: | Friedemann Hagenbuch, Hans M. Olbrich, Dieter Ebert, G. Valerius, Freimut D. Juengling, Christine Paris |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Time Factors Alcohol Drinking Temperance Prefrontal Cortex Craving Severity of Illness Index 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Reward Memory Cerebellum mental disorders medicine Humans Attention Demography Cerebral Cortex Putamen Alcohol dependence Brain General Medicine Dorsolateral prefrontal cortex Diagnostic and Statistical Manual of Mental Disorders Disruptive Impulse Control and Conduct Disorders Psychiatry and Mental health medicine.anatomical_structure Cerebral blood flow Cue reactivity Cerebrovascular Circulation Positron-Emission Tomography Brain stimulation reward medicine.symptom Cues Psychology Insula Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | The Australian and New Zealand journal of psychiatry. 40(2) |
| ISSN: | 0004-8674 |
| Popis: | Objective: Craving for alcohol is probably involved in acquisition and maintenance of alcohol dependence to a substantial degree. However, the brain substrates and mechanisms that underlie alcohol craving await more detailed elucidation. Method: Positron emission tomography was used to map regional cerebral blood flow (CBF) in 21 detoxified patients with alcohol dependence during exposure to alcoholic and non-alcoholic beverages. Results: During the alcohol condition compared with the control condition, significantly increased CBF was found in the ventral putamen. Additionally, activated areas included insula, dorsolateral prefrontal cortex and cerebellum. Cerebral blood flow increase in these regions was related to self-reports of craving assessed in the alcoholic patients. Conclusions: In this investigation, cue-induced alcohol craving was associated with activation of brain regions particularly involved in brain reward mechanisms, memory and attentional processes. These results are consistent with studies on craving for other addictive substances and may offer strategies for more elaborate studies on the neurobiology of addiction. |
| Databáze: | OpenAIRE |
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