Some naturally occurring compounds that increase longevity and stress resistance in model organisms of aging
| Autor: | Silvestre Alavez, Adriana Alarcón-Aguilar, Norma Edith López-Diazguerrero, Laura J. Pérez-Flores, Darío R. Gómez-Linton, Mina Königsberg |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging media_common.quotation_subject Longevity ved/biology.organism_classification_rank.species Resveratrol Biology Pharmacology Models Biological 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animals Humans Model organism Beneficial effects media_common Biological Products ved/biology Stress resistance Adaptation Physiological Spermidine 030104 developmental biology chemistry Curcumin Geriatrics and Gerontology Gerontology 030217 neurology & neurosurgery Signal Transduction Sulforaphane |
| Zdroj: | Biogerontology. 20:583-603 |
| ISSN: | 1573-6768 1389-5729 |
| Popis: | Humans and other organisms show age-related signs of deterioration, which makes aging an interesting process to study. In the present work, we review the anti-aging evidence of several of the most promising natural compounds. Quercetin, rapamycin, resveratrol, spermidine, curcumin or sulforaphane administration increase longevity and stress resistance in model organisms such as yeasts, nematodes, flies and mice. Even more, rapamycin, resveratrol, and curcumin are currently in preclinical tests on the Interventions Testing Program of the National Institute on Aging due to their encouraging results in model organisms. The potential mechanisms underlying the beneficial effects of these compounds are briefly described. |
| Databáze: | OpenAIRE |
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