Impaired gastrocolonic response and peristaltic reflex in slow-transit constipation: role of 5-HT3 pathways
| Autor: | Chung Owyang, Einar Björnsson, William D. Chey, William L. Hasler, Michelle L. Woods, Forrest G. Hooper |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
medicine.medical_specialty Constipation Colon Duodenum Physiology Muscarinic Agonists Gastroenterology Catheterization Descending colon Physiology (medical) Internal medicine Reflex medicine Humans Slow transit constipation Gastrointestinal Transit Antrum Peristalsis Hepatology business.industry Colonic inertia Stomach Muscle Smooth Bethanechol Lipids medicine.anatomical_structure Muscle Tonus Receptors Serotonin Chronic Disease Female Receptors Serotonin 5-HT3 medicine.symptom business Colonic motility |
| Zdroj: | American Journal of Physiology-Gastrointestinal and Liver Physiology. 283:G400-G407 |
| ISSN: | 1522-1547 0193-1857 |
| DOI: | 10.1152/ajpgi.00082.2001 |
| Popis: | Colonic motility is modulated by the 5-hydroxytryptamine (5-HT)3-dependent gastrocolonic response and 5-HT3-independent peristaltic reflex. We compared descending colon tone responses to antral distension, duodenal lipid perfusion, and colonic distension after double-blind placebo or granisetron in 13 healthy volunteers and nine slow-transit constipated patients. Antral distension (100–300 ml) and duodenal lipids (3 kcal/min) evoked increases in colon tone in volunteers, which were blunted in constipated patients ( P < 0.05). Granisetron (10 μg/kg) reduced responses to antral distension and lipids in volunteers and to lipids in constipated patients ( P < 0.05). The ascending contraction of the peristaltic reflex was blunted in constipated patients ( P < 0.05), whereas descending responses were similar. Granisetron did not modify the peristaltic reflex. Colonic responses to bethanechol were similar in patients and volunteers. In conclusion, antral distension- and duodenal lipid-activated gastrocolonic responses and ascending contractions of the peristaltic reflex are impaired with slow-transit constipation with loss of both 5-HT3-dependent and -independent function. Thus abnormalities of neural reflex modulation of colonic motor function may play pathophysiological roles in slow-transit constipation. |
| Databáze: | OpenAIRE |
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