The Role of lncRNAs in Gene Expression Regulation through mRNA Stabilization
| Autor: | Izortze Santin, Ainara Castellanos-Rubio, Ane Olazagoitia-Garmendia, Itziar Gonzalez-Moro, Maialen Sebastian-delaCruz |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 Cellular homeostasis RNA-binding protein Review Biology Biochemistry 03 medical and health sciences 0302 clinical medicine microRNA Gene expression Genetics mRNA stability Molecular Biology Regulation of gene expression long non-coding RNA Translation (biology) MRNA stabilization RNA binding protein Long non-coding RNA Cell biology lcsh:Genetics 030104 developmental biology 030220 oncology & carcinogenesis gene expression |
| Zdroj: | Addi. Archivo Digital para la Docencia y la Investigación instname Non-Coding RNA, Vol 7, Iss 3, p 3 (2021) Universidad de Cantabria (UC) Addi: Archivo Digital para la Docencia y la Investigación Universidad del País Vasco Non-Coding RNA |
| Popis: | mRNA stability influences gene expression and translation in almost all living organisms, and the levels of mRNA molecules in the cell are determined by a balance between production and decay. Maintaining an accurate balance is crucial for the correct function of a wide variety of biological processes and to maintain an appropriate cellular homeostasis. Long non-coding RNAs (lncRNAs) have been shown to participate in the regulation of gene expression through different molecular mechanisms, including mRNA stabilization. In this review we provide an overview on the molecular mechanisms by which lncRNAs modulate mRNA stability and decay. We focus on how lncRNAs interact with RNA binding proteins and microRNAs to avoid mRNA degradation, and also on how lncRNAs modulate epitranscriptomic marks that directly impact on mRNA stability. LncRNA work in author’s laboratory is supported by European Foundation for the Study of Diabetes (EFSD)-EFSD/JDRF/Lilly Programme on Type 1 Diabetes Research and the Spanish Ministry of Science, Innovation and Universities (PID2019-104475GA-I00) to I.S; and Spanish Ministry of Science, Innovation and Universities (SAF2017-91873-EXP and PGC2018-097573-A-I00) to ACR. M.S.D. and I.G.M. are supported by a Predoctoral Fellowship Grant from the UPV/EHU (Universidad del País Vasco/Euskal Herriko Unibertsitatea) and A.O.G. is supported by a Predoctoral Fellowship Grant from the Education Department of Basque Government. |
| Databáze: | OpenAIRE |
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