Design and Control of Nanoconfinement to Achieve Magnetic Resonance Contrast Agents with High Relaxivity
| Autor: | Gunnar Schütz, Kerstin Malzahn, Katharina Landfester, Isabel Schlegel, Manfred Wagner, Farnoosh Roohi, Kerstin Münnemann, Andreas Ide, Daniel Crespy, Sandro Ebert, Oliver Neudert |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Materials science Gadolinium Biomedical Engineering Contrast Media Pharmaceutical Science chemistry.chemical_element Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Nanocapsules Biomaterials Mice Organometallic Compounds medicine Animals Humans Tissue Distribution Tissue distribution Semipermeable membrane chemistry.chemical_classification High concentration Aqueous solution medicine.diagnostic_test Signal Processing Computer-Assisted Magnetic resonance imaging Polymer 021001 nanoscience & nanotechnology Magnetic Resonance Imaging 0104 chemical sciences Solutions chemistry 0210 nano-technology Biomedical engineering |
| Zdroj: | Advanced Healthcare Materials. 5:567-574 |
| ISSN: | 2192-2640 |
| DOI: | 10.1002/adhm.201500748 |
| Popis: | The enhanced relaxation of hydrogen atoms of surrounding water from suitable contrast agent promotes magnetic resonance imaging as one of the most important medical diagnosis technique. The key challenge for the preparation of performant contrast agents for magnetic resonance imaging with high relaxivity is to ensure a high local concentration of contrast agent while allowing a contact between water and the contrast agent. Both requirements are answered by tailoring a semipermeable confinement for a gadolinium complex used as contrast agent. A locally high concentration is achieved by successfully encapsulating the complex in polymer nanocontainers that serves to protect and retain the complex inside a limited space. The access of water to the complex is achieved by carefully controlling the chemistry of the shell and the core of the nanocontainers. The confinement of the nanocontainers enables an increased relaxivity compared to an aqueous solution of the contrast agent. The nanocontainers are successfully applied in vivo to yield enhanced contrast in magnetic resonance imaging. |
| Databáze: | OpenAIRE |
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