Species differences of the stereoselective binding of phenprocoumon and warfarin enantiomers to serum albumins
| Autor: | Eberhard Jähnchen, Walter E. Müller, Willy Schmidt, Uwe Wollert, Nigel A. Brown |
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| Rok vydání: | 1979 |
| Předmět: |
Protein Conformation
Stereochemistry Immunology Serum albumin Plasma protein binding 4-Hydroxycoumarins Phenprocoumon Structure-Activity Relationship chemistry.chemical_compound Stereospecificity Species Specificity medicine Animals Humans Bovine serum albumin Serum Albumin Pharmacology Chromatography biology Circular Dichroism Serum Albumin Bovine Stereoisomerism Human serum albumin chemistry biology.protein Cattle Warfarin Enantiomer Protein Binding medicine.drug |
| Zdroj: | Comparative Biochemistry and Physiology Part C: Comparative Pharmacology. 62:101-105 |
| ISSN: | 0306-4492 |
| DOI: | 10.1016/0306-4492(79)90107-2 |
| Popis: | 1. The stereospecificity of the interaction of the enantiomers of the anticoagulent drugs warfarin and phenprocoumon with bovine and rat serum albumin was investigated using equilibrium dialysis and circular dichroism measurements and compared with the stereospecific binding of both drugs to human serum albumin. 2. Bovine serum albumin totally lacks any ability to bind the enantiomers of both drugs stereoselectively. 3. Rat serum albumin binds R(+)phenprocoumon more strongly than S(−)phenprocoumon, but binds S(−)warfarin more strongly than R(+)warfarin. 4. The reason for the opposed stereospecificity of rat serum albumin seems to be a different binding mechanism of the 4-hydroxy-coumarin moieties. |
| Databáze: | OpenAIRE |
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