Immunity After Childhood Vaccinations in Perinatally HIV-exposed Children With and Without HIV Infection in Latin America
| Autor: | Maria Isabel de Moraes-Pinto, Esau Joao, Marisa Márcia Mussi-Pinhata, Marcelo C. Scotta, R B Pierre, Irene Foradori, Noris Pavia Ruz, George K. Siberry, Margot Krauss, Lenka Kolevic Roca, Regina Célia de Menezes Succi, Daisy Maria Machado, D. Robert Harris, Rohan Hazra |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Microbiology (medical) Pediatrics medicine.medical_specialty Vaccination Coverage Adolescent 030231 tropical medicine HIV Infections Antibodies Viral medicine.disease_cause Rubella Measles Article Young Adult 03 medical and health sciences symbols.namesake 0302 clinical medicine Pregnancy Immunity Humans Medicine Prospective Studies 030212 general & internal medicine Child Maternal-Fetal Exchange Fisher's exact test Hepatitis B virus Vaccines business.industry Tetanus Infant Newborn Infant Environmental Exposure medicine.disease Antibodies Bacterial Vaccination Titer Latin America Infectious Diseases Caribbean Region Child Preschool Pediatrics Perinatology and Child Health symbols Female business |
| Zdroj: | Pediatric Infectious Disease Journal. 37:304-309 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0000000000001831 |
| Popis: | BACKGROUND Perinatally HIV-infected (PHIV) children are at risk for under-vaccination and poor vaccine response at 4 years of age. Childhood vaccine coverage and immune response were compared between PHIV and HIV-exposed uninfected (HEU) children in Latin America and the Caribbean. METHODS PHIV and HEU children were enrolled prospectively at 15 sites from 2002 to 2009. Full vaccination by age 4 years was defined as: 3 hepatitis B virus vaccine doses; 4 tetanus toxoid-containing vaccine doses; 3 doses of Haemophilus influenzae type b vaccine by age 12 months or ≥1 dose given after age 12 months; one measles-containing vaccine dose; one rubella-containing vaccine dose. Immunity was defined by serum antibody titer. Fisher exact test (for categorical measures) and t test (for continuous measures) were used for comparisons. RESULTS Among 519 children seen at age 4 years, 191 had serum specimens available (137 PHIV, 54 HEU). Among those with specimens available, 29.3% initiated combination antiretroviral therapy (cART) |
| Databáze: | OpenAIRE |
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