Mangromicins A and B: structure and antitrypanosomal activity of two new cyclopentadecane compounds from Lechevalieria aerocolonigenes K10-0216

Autor: Kazuro Shiomi, Junya Ochiai, Satoshi Ōmura, Masato Iwatsuki, Takuji Nakashima, Atsuko Matsumoto, Aki Ishiyama, Yoshiyuki Kamiya, Kazuhiko Otoguro, Kenichiro Nagai, Yōko Takahashi
Rok vydání: 2013
Předmět:
Zdroj: The Journal of Antibiotics. 67:253-260
ISSN: 1881-1469
0021-8820
DOI: 10.1038/ja.2013.129
Popis: Two new cyclopentadecane antibiotics, named mangromicins A and B, were separated out from the culture broth of Lechevalieria aerocolonigenes K10-0216 by Diaion HP-20, silica gel and ODS column chromatography, and were finally purified by HPLC. The chemical structures of the two novel compounds were elucidated by instrumental analyses, including various NMR, MS and X-ray crystallography. Mangromicins A and B consist of cyclopentadecane skeletons with a tetrahydrofuran unit and a 5,6-dihydro-4-hydroxy-2-pyrone moiety. Mangromicins A and B showed in vitro antitrypanosomal activity with IC50 values of 2.4 and 43.4 μg ml(-1), respectively. The IC50 values of both compounds were lower than those of cytotoxicity against MRC-5 human fetal lung fibroblast cells.
Databáze: OpenAIRE
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