Genetic Characterization of a Novel HIV-1 Second-Generation Recombinant Form Originating from CRF86_BC and a Unique Recombinant Form in Yunnan, China

Autor:	Qiang Ma, Zheng-Xu Li, Ya-Ting Chen, Li An, Xian-Ya Dong, Lei Zhao, Ying-Na Xie, Xin Chen, Dong-Xu Liu, An-Yan Hu
Rok vydání:	2021
Předmět:	China Genetic diversity Genotype Immunology Human immunodeficiency virus (HIV) virus diseases HIV Infections Genome Viral Sequence Analysis DNA Biology medicine.disease_cause Virology law.invention Infectious Diseases law HIV-1 Recombinant DNA medicine Humans human activities Phylogeny
Zdroj:	AIDS Research and Human Retroviruses. 37:985-989
ISSN:	1931-8405 0889-2229
DOI:	10.1089/aid.2021.0121
Popis:	Yunnan is the first place where human immunodeficiency virus type 1 (HIV-1) became prevalent in China, and it is also the place with the most complicated HIV-1 genetic diversity in China. On October 23, 2019, a patient newly diagnosed with acquired immunodeficiency syndrome from a hospital in Baoshan, Yunnan, was recruited for genetic analysis. Near full-length genome of HIV-1 was amplified from the plasma sample. Phylogenetic analysis revealed that this sequence (BS6F24) has a close relationship with CRF86_BC and a unique recombinant form (URF) (KY406739), which was formed by recombination of subtypes B and C. Bootscan analysis confirmed that the first part (HXB2:1022-5832) and last part (HXB2:5833-9120) genomes of BS6F24 had the same recombinant structures as KY406739 and CRF86_BC, respectively. A second-generation recombinant form that originated from CRF86_BC and a URF were reported for the first time. This indicates the need for continuous monitoring of the genetic diversity of HIV-1 in Yunnan, China.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::789c469ac1c9d6cfe8c3a9fbc537a851 https://doi.org/10.1089/aid.2021.0121 Zobrazit plný text záznamu