Effects of MPTP, MPP+ and paraquat on mitochondrial potential and oxidative stress
| Autor: | Stephen C. Bondy, Charles E. Lambert |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Male
Paraquat 1-Methyl-4-phenylpyridinium Pyridines Neurotoxins Pyridinium Compounds Mitochondrion medicine.disease_cause General Biochemistry Genetics and Molecular Biology Membrane Potentials chemistry.chemical_compound medicine Animals heterocyclic compounds General Pharmacology Toxicology and Pharmaceutics Synaptosome Membrane potential MPTP Cell Membrane Brain Biological membrane Intracellular Membranes General Medicine Rats Inbred F344 Mitochondria Rats Kinetics chemistry Biochemistry 1-Methyl-4-phenyl-1 2 3 6-tetrahydropyridine Biophysics Calcium Lipid Peroxidation Oxidative stress Synaptosomes |
| Zdroj: | Life Sciences. 44:1277-1284 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(89)90365-2 |
| Popis: | The effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+) and 1,1-dimethyl-4,4-bipyridinium (paraquat) upon the electrical potential across the plasma and mitochondrial membranes within synaptosomes has been investigated. MPTP selectively depressed plasma membrane potential while MPP+ specifically reduced mitochondrial potential. The structurally similar compound paraquat had no effect on either membrane potential. Enhancement of the lipid peroxidative activity with an Fe-ADP complex depressed both potentials. Paraquat effected increased peroxidative activity in brain homogenates that was less pronounced than that due to Fe-ADP. MPTP reduced basal but stimulated Fe-ADP enhanced peroxidation. The mechanisms underlying the toxicity of MPP+ are likely to differ from those of paraquat, primarily involving impaired mitochondrial function rather than increased oxidative stress. |
| Databáze: | OpenAIRE |
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