Differential regional expression of brain-derived neurotrophic factor following olfactory fear learning
| Autor: | Kerry J. Ressler, Lisa Stanek-Rattiner, Seth V. Jones, Michael Davis |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Olfactory system Cognitive Neuroscience Olfaction Amygdala Article Mice Cellular and Molecular Neuroscience Piriform cortex medicine Animals RNA Messenger Brain-derived neurotrophic factor Brain-Derived Neurotrophic Factor musculoskeletal neural and ocular physiology Association Learning Fear Olfactory Pathways Olfactory Bulb Associative learning Olfactory bulb Mice Inbred C57BL Neuropsychology and Physiological Psychology medicine.anatomical_structure Gene Expression Regulation nervous system Odorants Psychology Neuroscience psychological phenomena and processes Basolateral amygdala |
| Zdroj: | Learning & Memory. 14:816-820 |
| ISSN: | 1549-5485 1072-0502 |
| Popis: | We examined brain-derived neurotrophic factor (BDNF) mRNA expression across the olfactory system following fear conditioning. Mice received 10 pairings of odor with footshock or equivalent unpaired odors and shocks. We found increased BDNF mRNA in animals receiving paired footshocks in the multiple regions examined including the posterior piriform cortex (PPC) and basolateral amygdala (BLA). This was in contrast to the unpaired and odor-alone treatments, where BDNF mRNA was increased in the olfactory bulb (OB) and anterior piriform cortex (APC) only, but not the higher olfactory areas. We propose that odor exposure increases expression of BDNF in the OB and APC while the PPC and BLA increase BDNF mRNA only when associative learning occurs. |
| Databáze: | OpenAIRE |
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